Hartford Hospital.
University of Connecticut.
Oncol Nurs Forum. 2024 Oct 17;51(6):565-575. doi: 10.1188/24.ONF.565-575.
To describe longitudinal oral health symptom patterns of patients receiving concurrent chemotherapy and radiation therapy for head and neck cancer (HNC) and examine associations between phenotypic characteristics, including human papillomavirus (HPV) status and oral health symptoms.
SAMPLE & SETTING: A pilot retrospective longitudinal chart review (N = 270) of patients with HNC at a northeastern U.S. regional cancer institute.
METHODS & VARIABLES: HPV status and oral health symptoms (pain, mucositis, taste alteration, xerostomia, dysphagia, and candidiasis) were examined during treatment (six weeks) and survivorship (three months). Latent transition analysis was conducted across each time point.
The latent transition analysis revealed classes with moderate to high symptom expression persisted into survivorship. The HPV-negative phenotype had higher symptom expression across treatment and survivorship.
Patients with HPV-negative HNC may require early intervention, while considering social determinants of health to attenuate symptom expression and improve outcomes.
描述接受头颈部癌症（HNC）同步放化疗的患者的纵向口腔健康症状模式，并研究表型特征（包括人乳头瘤病毒[HPV]状态）与口腔健康症状之间的关联。
美国东北部地区癌症研究所 270 例 HNC 患者的试点回顾性纵向图表审查。
在治疗期间（六周）和生存期间（三个月）检查 HPV 状态和口腔健康症状（疼痛、黏膜炎、味觉改变、口干、吞咽困难和念珠菌病）。在每个时间点进行潜在转移分析。
潜在转移分析显示，在生存期间，中度至高度症状表达的类持续存在。HPV 阴性表型在治疗和生存期间的症状表达更高。
HPV 阴性 HNC 患者可能需要早期干预，同时考虑健康的社会决定因素，以减轻症状表达并改善结局。
