Hadjis N S, Griffin S, Blumgart L H, Knox P
Clin Sci (Lond). 1986 Jan;70(1):73-9. doi: 10.1042/cs0700073.
Reduced levels of plasma fibronectin have been implicated in the septicaemia and/or endotoxaemia that can accompany trauma or burns. Patients undergoing surgery for the relief of obstructive jaundice are also at risk of developing endotoxaemia or septicaemia. In this study, levels of plasma fibronectin were measured by immunoassay and bioassay in 16 such patients. No patient had a significantly reduced level of plasma fibronectin. Even in the case of patients developing a fatal septicaemia and general system failure there was no significant decrease in circulating fibronectin. It is concluded that measurement of plasma fibronectin is of no prognostic value and similarly infusion of fibronectin-rich cryoprecipitate would be of no therapeutic benefit.
血浆纤连蛋白水平降低与创伤或烧伤后可能伴随的败血症和/或内毒素血症有关。接受手术以缓解梗阻性黄疸的患者也有发生内毒素血症或败血症的风险。在本研究中，通过免疫测定和生物测定法对16例此类患者的血浆纤连蛋白水平进行了测量。没有患者的血浆纤连蛋白水平显著降低。即使是发生致命败血症和全身系统衰竭的患者，循环中的纤连蛋白也没有显著下降。得出的结论是，血浆纤连蛋白的测量没有预后价值，同样，输注富含纤连蛋白的冷沉淀也没有治疗益处。
