Xie Hanhan, Cao Chun, Shu Dan, Liu Tong, Zhang Tao
The Second Affiliated Hospital of Chengdu Medical College, China Nation Nuclear Corporation 416 Hospital, Chengdu, China.
School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, China.
Front Med (Lausanne). 2024 Oct 7;11:1449037. doi: 10.3389/fmed.2024.1449037. eCollection 2024.
Ferroptosis is a type of regulated cell death that occurs due to the iron-dependent accumulation of lethal reactive oxygen species (ROS) from lipids. Ferroptosis is characterized by distinct morphological, biochemical, and genetic features that differentiate it from other regulated cell death (RCD) types, which include apoptosis, various necrosis types, and autophagy. Recent reports show that ferritin formation is correlated to many disorders, such as acute injury, infarction, inflammation, and cancer. Iron uptake disorders have also been associated with intestinal epithelial dysfunction, particularly inflammatory bowel disease (IBD). Studies of iron uptake disorders may provide new insights into the pathogenesis of IBD, thereby improving the efficacy of medical interventions. This review presents an overview of ferroptosis, elucidating its fundamental mechanisms and highlighting its significant involvement in IBD.
铁死亡是一种程序性细胞死亡，它是由于脂质中依赖铁的致死性活性氧（ROS）积累而发生的。铁死亡具有独特的形态、生化和遗传特征，这些特征使其与其他程序性细胞死亡（RCD）类型区分开来，其他类型包括凋亡、各种坏死类型和自噬。最近的报告表明，铁蛋白的形成与许多疾病相关，如急性损伤、梗死、炎症和癌症。铁摄取障碍也与肠道上皮功能障碍有关，尤其是炎症性肠病（IBD）。对铁摄取障碍的研究可能为IBD的发病机制提供新的见解，从而提高医学干预的效果。本综述概述了铁死亡，阐明了其基本机制，并强调了其在IBD中的重要作用。
