Renard Dimitri, Sangare Birama, Youssouf Ansma, Thouvenot Eric
Department of Neurology, CHU Nîmes, University Montpellier, Montpellier, France.
Institut de Génomique Fonctionnelle, CNRS UMR5203, INSERM 1191, University Montpellier, Montpellier, France.
J Alzheimers Dis Rep. 2024 Jul 23;8(1):1089-1092. doi: 10.3233/ADR-240086. eCollection 2024.
Alzheimer's disease and cerebral amyloid angiopathy (CAA) are often associated. Amyloid accumulation within leptomeningeal and small/median-sized cerebral blood vessels in CAA results in vessel fragility, leading to spontaneous leptomeningeal bleeding, lobar intracerebral hemorrhage (ICH) and cerebral microbleeds. CAA is also associated with non-traumatic subdural hematoma. The role of CAA-related vessel fragility in hemorrhagic complications after trauma, brain surgery, and intracranial drain insertion in CAA is unknown. We present two sporadic CAA patients with intracranial drain-related ICH, probably due to different underlying mechanisms, related to indirect and direct CAA-associated vessel fragility.
阿尔茨海默病与脑淀粉样血管病（CAA）常相关联。CAA中软脑膜及中小脑血 管内的淀粉样物质积聚导致血管脆性增加，进而引发自发性软脑膜出血、脑叶脑出血（ICH）和脑微出血。CAA还与非创伤性硬膜下血肿有关。CAA相关的血管脆性在CAA患者创伤、脑手术后及颅内引流管置入后出血并发症中的作用尚不清楚。我们报告了2例散发性CAA患者发生与颅内引流管相关的ICH，可能由于不同的潜在机制，与CAA相关的间接和直接血管脆性有关。
