Jenabi Ensiyeh, Najafi-Vosough Roya, Nazari Arshia
Mother and Child Care Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.
Open Med (Wars). 2024 Oct 18;19(1):20241047. doi: 10.1515/med-2024-1047. eCollection 2024.
Some studies have indicated a notable association between obesity and placenta accreta spectrum (PAS), while others have not reported. Hence, we performed a meta-analysis to explore the association between obesity and the risk of PAS.
To explore the association between obesity and PAS through observational studies, we conducted a systematic search across PubMed, Web of Science, Google scholar, and Scopus databases up to March 30, 2024. The meta-analysis utilized a random-effect model, with the quality of included studies assessed using the Newcastle-Ottawa scale. A significance level of less than 0.05 was considered statistically significant using Stata software, version 14 (StataCorp, College Station, TX, USA).
The association between obesity and PAS risk in crude studies showed significance (1.51 [95% CI: 1.19, 1.82; = 0.0%]). However, in adjusted studies, the association was not significant (1.25 [95% CI: 0.45, 2.05; = 52.0%]).
These findings suggest that obesity has been proposed as potentially associated with a higher risk of PAS, particularly evident in crude studies. However, it is imperative to conduct prospective cohort studies with a large sample size and meticulous control of confounding variables to further elucidate this relationship.
一些研究表明肥胖与胎盘植入谱系障碍（PAS）之间存在显著关联，而其他研究则未报告此关联。因此，我们进行了一项荟萃分析，以探讨肥胖与PAS风险之间的关联。
为了通过观察性研究探索肥胖与PAS之间的关联，我们对截至2024年3月30日的PubMed、科学网、谷歌学术和Scopus数据库进行了系统检索。荟萃分析采用随机效应模型，使用纽卡斯尔-渥太华量表评估纳入研究的质量。使用Stata软件14版（美国德克萨斯州大学站市StataCorp公司），将显著性水平设定为小于0.05作为具有统计学意义的标准。
在未调整的研究中，肥胖与PAS风险之间的关联具有显著性（1.51 [95%置信区间：1.19，1.82；P = 0.0%]）。然而，在调整后的研究中，该关联不具有显著性（1.25 [95%置信区间：0.45，2.05；P = 52.0%]）。
这些发现表明，肥胖被认为可能与PAS的较高风险相关，在未调整的研究中尤为明显。然而，必须进行大样本量且严格控制混杂变量的前瞻性队列研究，以进一步阐明这种关系。
