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提高流行病学数据在人类健康风险评估中的整合度:风险评估人员告诉我们他们想要什么。

Improving the integration of epidemiological data into human health risk assessment: What risk assessors told us they want.

作者信息

Phillips Carl V, Burstyn Igor, Miller David J, Hamade Ali K, Avanasi Raghavendhran, Boon Denali, Rege Saumitra V, Déglin Sandrine E

机构信息

Epiphi Consulting, Nashua, NH, United States of America.

Department of Environmental and Occupational Health, Drexel University, Philadelphia, PA, United States of America.

出版信息

Glob Epidemiol. 2024 Sep 28;8:100167. doi: 10.1016/j.gloepi.2024.100167. eCollection 2024 Dec.

DOI:10.1016/j.gloepi.2024.100167
PMID:39435396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11492098/
Abstract

One of the practical contributions of epidemiology studies is to inform risk assessment and management to protect public health. However, there is a perception among some that environmental and occupational epidemiology is falling short of satisfying the needs of risk assessors. The specific reasons for this are not clearly understood. To help identify the points of dissatisfaction and possible areas for mutual learning, we conducted a survey of risk assessors, seeking their opinions of epidemiology research. We present a few quantitative measures and a thematic analysis of responses to open-ended questions. Survey results suggest that some risk assessors (with some adamant exceptions) believe that epidemiology has great potential to contribute to risk assessment but can be deficient in many ways. For example, respondents identified the lack of full disclosure of methods, deficiencies in exposure assessment, the absence of comprehensive uncertainty analyses, and the failure to investigate or explore thresholds of effects as some of the common shortcomings. These could be straightforward to address. Respondents also brought up a wide collection of more complicated and subtle concerns that could lead to further improvement of useful results. We identify areas where mutually-educating interdisciplinary dialogue seems particularly promising. Epidemiology research is expensive, and risk management decisions even more so; therefore, it is desirable for the risk assessment and epidemiologic communities to work toward making epidemiologic research more useful for informing decisions.

摘要

流行病学研究的实际贡献之一是为风险评估和管理提供信息,以保护公众健康。然而,一些人认为环境与职业流行病学未能满足风险评估者的需求。对此具体原因尚不清楚。为了帮助找出不满之处以及相互学习的可能领域,我们对风险评估者进行了一项调查,征求他们对流行病学研究的意见。我们给出了一些定量措施以及对开放式问题回答的主题分析。调查结果表明,一些风险评估者(有一些坚定的例外情况)认为流行病学对风险评估有很大贡献潜力,但在许多方面可能存在不足。例如,受访者指出方法未充分披露、暴露评估存在缺陷、缺乏全面的不确定性分析以及未调查或探讨效应阈值是一些常见的缺点。这些问题可能很容易解决。受访者还提出了一系列更复杂、更微妙的问题,这些问题可能会带来更有用结果的进一步改进。我们确定了跨学科相互教育对话似乎特别有前景的领域。流行病学研究成本高昂,风险管理决策更是如此;因此,风险评估界和流行病学领域应努力使流行病学研究对决策更有帮助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/605f/11492098/c42f4381ca11/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/605f/11492098/f9a8356c8b8a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/605f/11492098/c42f4381ca11/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/605f/11492098/f9a8356c8b8a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/605f/11492098/c42f4381ca11/gr2.jpg

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本文引用的文献

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Environmental epidemiology and risk assessment: Exploring a path to increased confidence in public health decision-making.环境流行病学与风险评估:探寻增强公共卫生决策信心之路。
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"Good Epidemiology Practice" Guidelines for Pesticide Exposure Assessment.“良好流行病学实践”指导原则下的农药暴露评估
Int J Environ Res Public Health. 2020 Jul 15;17(14):5114. doi: 10.3390/ijerph17145114.
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Epidemiology and risk assessment.流行病学与风险评估。
流行病学中混淆因素的更好处理所面临的嘲弄:估计值变化谬误。
Glob Epidemiol. 2024 Sep 26;8:100166. doi: 10.1016/j.gloepi.2024.100166. eCollection 2024 Dec.
Am J Epidemiol. 1998 Nov 15;148(10):929-36. doi: 10.1093/oxfordjournals.aje.a009569.