Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Taixing Second People's Hospital, Taixing, China.
J Orthop Surg (Hong Kong). 2024 Sep-Dec;32(3):10225536241293489. doi: 10.1177/10225536241293489.
The uric acid-to-high-density lipoprotein cholesterol ratio (UHR) has emerged as a novel indicator of inflammatory and metabolic status. This study aims to examine the association between UHR and bone mineral density (BMD), as well as the risk of osteoporosis, in individuals aged ≥50 years. This cross-sectional study used data from the National Health and Nutrition Examination Survey, focusing on participants aged ≥50 years. Femoral neck BMD (FN-BMD) was measured using dual-energy X-ray absorptiometry. Linear regression models were employed to examine the association between UHR and FN-BMD. Additionally, generalised additive models were used to assess the nonlinear relationship between UHR and FN-BMD. Logistic regression models were employed to evaluate the association between UHR and the risk of osteoporosis. Finally, the study included 2963 adults with a mean age of 64.16 ± 8.92 years. Linear regression analyses revealed a positive association between UHR and FN-BMD, regardless of covariate adjustments. Logistic regression analyses indicated that elevated UHR was associated with a reduced risk of osteoporosis with or without covariate adjustments. Subgroup analyses revealed that the positive association between UHR and BMD was significant in individuals aged ≥65 years but not in those aged 50 to 64 years. Interaction analyses by age showed significant differences after adjusting for all covariates. Clinicians should be vigilant regarding the potential risk of osteoporosis in individuals with a low UHR. UHR might serve as a risk indicator for osteoporosis.
尿酸与高密度脂蛋白胆固醇比值（UHR）已成为炎症和代谢状态的新指标。本研究旨在探讨 UHR 与≥50 岁人群骨密度（BMD）及骨质疏松风险之间的关系。本横断面研究使用了国家健康和营养调查的数据，主要关注≥50 岁的参与者。使用双能 X 射线吸收法测量股骨颈 BMD（FN-BMD）。采用线性回归模型探讨 UHR 与 FN-BMD 之间的关系。此外，采用广义加性模型评估 UHR 与 FN-BMD 之间的非线性关系。采用 logistic 回归模型评估 UHR 与骨质疏松风险之间的关系。最终，该研究纳入了 2963 名平均年龄为 64.16±8.92 岁的成年人。线性回归分析显示，UHR 与 FN-BMD 呈正相关，无论是否进行协变量调整。Logistic 回归分析表明，无论是否进行协变量调整，UHR 升高与骨质疏松风险降低相关。亚组分析显示，在≥65 岁的人群中，UHR 与 BMD 之间的正相关关系显著，但在 50 至 64 岁的人群中则不显著。在调整所有协变量后，年龄的交互分析显示出显著差异。临床医生应警惕 UHR 较低的个体发生骨质疏松的潜在风险。UHR 可能是骨质疏松的风险指标。
