Zou Yueli, Wu Yaning, An Helin, Song Mingzhao, Zhang Jingyi, Yu Xiujun, Li Yi
Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, People's Republic of China.
Key Laboratory of Clinical Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, China.
Discov Oncol. 2024 Oct 22;15(1):578. doi: 10.1007/s12672-024-01443-w.
This study aims to analyze the clinical features, Radiological findings and diagnostic characteristics (tissue biopsy, flow cytometry and cerebrospinal fluid cytology) of primary central nervous system lymphoma (PCNSL). To improve the diagnosis of the disease.
A total of 19 patients with primary central nervous system lymphoma admitted to the Second Hospital of Hebei Medical University from 2014 to 2023 were selected. The clinical data of the patients were retrospectively analyzed. Combined with the relevant literature, the clinical characteristics of PCNSL patients were analyzed to assist the diagnosis.
Most of the patients were middle-aged and elderly patients (65 years old), and the main clinical manifestations showed no obvious specificity, including headache, dizziness and limb weakness. Radiological findings showed that common site of currence were located in the brain parenchyma. The PCNSL subtype of 19 patients was all diffuse large B cell subtype by cytology, flow cytometry or histopathology. Six cases were diagnosed by biopsy pathology and 11 cases were diagnosed by flow cytometry of cerebrospinal fluid. In all patients diagnosed with PCNSL by clinical cytology (CSF cytology and flow cytometry), abnormal cells were found on CSF examination.
The pathological type of primary central nervous system lymphoma was diffuse large B-cell subtype, with diverse clinical manifestations and multiple. Both tissue directed biopsy and flow cytometry could effectively assist clinical diagnosis. Early and timely diagnosis and intervention are of great significance for delaying the disease process and reducing the economic burden of patients and families.
本研究旨在分析原发性中枢神经系统淋巴瘤（PCNSL）的临床特征、影像学表现及诊断特点（组织活检、流式细胞术和脑脊液细胞学检查），以提高该病的诊断水平。
选取2014年至2023年在河北医科大学第二医院收治的19例原发性中枢神经系统淋巴瘤患者，对患者的临床资料进行回顾性分析，并结合相关文献，分析PCNSL患者的临床特征以辅助诊断。
患者多为中老年（≥65岁），主要临床表现无明显特异性，包括头痛、头晕及肢体无力等。影像学表现显示，病变好发部位位于脑实质。19例患者经细胞学、流式细胞术或组织病理学检查，PCNSL亚型均为弥漫大B细胞亚型。6例经活检病理确诊，11例经脑脊液流式细胞术确诊。所有经临床细胞学（脑脊液细胞学和流式细胞术）确诊为PCNSL的患者脑脊液检查均发现异常细胞。
原发性中枢神经系统淋巴瘤病理类型为弥漫大B细胞亚型为主型，临床表现多样且多发。组织定向活检及流式细胞术均能有效辅助临床诊断。早期及时诊断并干预对延缓病情进展、减轻患者及家庭经济负担具有重要意义。
