Division of Pediatric Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Sao Paulo, Brazil; Center for Regenerative Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, Division of Pediatric Surgery, Department of Surgery, The Ohio State University College of Medicine, Columbus, Ohio.
Division of Pediatric Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Sao Paulo, Brazil.
J Surg Res. 2024 Nov;303:613-627. doi: 10.1016/j.jss.2024.09.059. Epub 2024 Oct 21.
Necrotizing enterocolitis (NEC) is a severe inflammatory disease of the gastrointestinal tract and one of the most common life-threatening emergencies affecting newborns. Intestinal fatty acid-binding protein (I-FABP) has been used as a possible marker of intestinal damage in NEC. We aimed to carry out a scoping review of all publications that explore the role of I-FABP in NEC to inspire new research into the potential utility of I-FABP as a marker of NEC.
We searched for relevant publications using the keywords "necrotizing enterocolitis," "intestinal fatty acid binding protein," "NEC," and "I-FABP" in the National Library of Medicine (PubMed/MEDLINE), Embase, SCOPUS, and Web of Science. Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews was used for reporting findings.
We identified 61 relevant articles, which we divided into clinical (n = 47) and experimental (n = 14) groups.
I-FABP is a promising marker of NEC, especially for NEC stage 2 and 3. Urinary I-FABP follows the same patterns as serum and plasma I-FABP. The definitive roles of I-FABP in early diagnosis of NEC, differential diagnosis in breast feeding, alimentary intolerance, and screening of surgical NEC need clarification and remain a challenge to investigators.
坏死性小肠结肠炎（NEC）是一种严重的胃肠道炎症性疾病，也是影响新生儿的最常见的危及生命的紧急情况之一。肠脂肪酸结合蛋白（I-FABP）已被用作 NEC 肠损伤的可能标志物。我们旨在对所有探索 I-FABP 在 NEC 中的作用的出版物进行范围综述，以激发对 I-FABP 作为 NEC 标志物的潜在效用的新研究。
我们使用国家医学图书馆（PubMed/MEDLINE）、Embase、SCOPUS 和 Web of Science 中的关键字“坏死性小肠结肠炎”、“肠脂肪酸结合蛋白”、“NEC”和“I-FABP”搜索相关出版物。扩展后的系统评价和荟萃分析的首选报告项目用于报告研究结果。
我们确定了 61 篇相关文章，我们将其分为临床（n=47）和实验（n=14）两组。
I-FABP 是 NEC 的一个有前途的标志物，特别是对于 NEC 2 期和 3 期。尿 I-FABP 与血清和血浆 I-FABP 呈现相同的模式。I-FABP 在 NEC 的早期诊断、母乳喂养的鉴别诊断、不耐受和手术 NEC 的筛查中的明确作用仍需阐明，这对研究人员来说仍是一个挑战。
