Wiersma J, Kastelijn J
Horm Res. 1986;23(2):106-11. doi: 10.1159/000180297.
The temporal effects of intracerebroventricular (icv) infusion of prolactin (PRL) on endogenous PRL secretion was investigated in intact, freely moving, cycling rats. An icv infusion of 10 ng or 100 ng rat-PRL/min from 13.00 to 17.00 h during the proestrous afternoon did not affect endogenous PRL secretion; infusion from 09.00 to 13.00 h showed a tendency to delay the time of onset of the PRL proestrous afternoon surge. The results do not indicate the involvement of an autoregulatory mechanism in the expression or the termination of the proestrous afternoon surge of PRL secretion.
在完整、自由活动、处于发情周期的大鼠中，研究了脑室内（icv）注入催乳素（PRL）对内源性PRL分泌的时间效应。在发情前期下午13:00至17:00期间，以每分钟10 ng或100 ng大鼠PRL的速率进行icv注入，并不影响内源性PRL分泌；在09:00至13:00期间注入则显示出延迟PRL发情前期下午分泌高峰开始时间的趋势。结果并未表明在PRL分泌发情前期下午高峰的表达或终止过程中存在自动调节机制。
