Yamamoto K, Sargent P A, Fisher M M, Youson J H
Hepatology. 1986 Jan-Feb;6(1):54-9. doi: 10.1002/hep.1840060111.
Transmission and scanning electron microscopy were utilized to follow the degeneration of bile ducts of lampreys (Petromyzon marinus L.) during metamorphosis. The convoluted bile ducts of larval lampreys are surrounded by rich sinusoids, but this intimate biliovascular relationship is lost during metamorphosis because the bile duct degeneration is accompanied by the development of thick periductal fibrosis. Lipocytes, which are present not only in the parenchyma but also in the interstitial tissue of the liver, increase in number in the periductal fibrous tissue, and their processes are directly opposed to collagen fibrils. Fibrillar materials in the dilated cisternae of the rough endoplasmic reticulum and the nuclear envelope of lipocytes are believed to be excreted by exocytosis in a manner similar to such excretion by fibroblasts. The findings suggest that lipocytes are responsible for the periductal fibrosis during biliary atresia in lampreys. This animal might prove to be an interesting model in which to study the biology and fibrogenic potential of lipocytes.
利用透射电子显微镜和扫描电子显微镜观察七鳃鳗（海七鳃鳗）变态过程中胆管的退化情况。幼体七鳃鳗的盘曲胆管被丰富的血窦包围，但在变态过程中这种紧密的胆管血管关系消失了，因为胆管退化伴随着导管周围厚纤维化的发展。脂肪细胞不仅存在于肝实质中，也存在于肝脏的间质组织中，在导管周围纤维组织中的数量增加，并且它们的突起直接与胶原纤维相对。脂肪细胞粗面内质网扩张的池和核膜中的纤维状物质被认为是以类似于成纤维细胞的这种排泄方式通过胞吐作用排出的。这些发现表明脂肪细胞是七鳃鳗胆道闭锁期间导管周围纤维化的原因。这种动物可能被证明是研究脂肪细胞生物学和纤维化潜能的一个有趣模型。
