Deng Jiayi, Wu Weihao, Zhang Zimiao, Ma Xiaomei, Chen Congjie, Huang Yanhong, Lai Yueyuan, Chen Liling, Chen Longtian
Department of Hematology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.
Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.
Clin Hemorheol Microcirc. 2025;89(1):69-81. doi: 10.3233/CH-242209.
The purpose of this research was to examine the relationship between the hemoglobin-to-red blood cell distribution width ratio (HRR) and cardiovascular disease (CVD)-related mortality in people who have diabetes.
Data derived from the National Health and Nutrition Examination Survey (NHANES), between the years 1999 to 2018, were meticulously analyzed. Mortality data, encompassing events until December 31, 2019, were systematically collected. A comprehensive group comprising of 8,732 participants were subjected to scrutiny, and subsequently, classified into four distinct groups predicated upon quartiles of baseline HRR levels: Q1 (n = 2,183), Q2 (n = 2,181), Q3 (n = 2,185), and Q4 (n = 2,183). The correlation between HRR and CVD-related mortality was examined through the use of survival curves and Cox proportional hazard regression models, the latter incorporating weights as advised by NHANES.
Among the 8,732 participants in the study cohort, CVD-related mortality was identified in 710 cases. The Kaplan-Meier analysis demonstrated a significant association, indicating that a decreased HRR was correlated with a reduction in survival in cases with CVD. Both univariate and multivariable Cox proportional hazard regression analyses consistently indicated that patients exhibiting a lower HRR exhibited a markedly elevated risk of CVD-related mortality in comparison to those with higher HRR. Notably, the correlation between HRR and decreasing CVD-related mortality was discerned to be non-linear.
In patients with diabetes, a decreased HRR was associated with an increased risk of CVD-related mortality.
本研究旨在探讨血红蛋白与红细胞分布宽度比值（HRR）与糖尿病患者心血管疾病（CVD）相关死亡率之间的关系。
对1999年至2018年期间美国国家健康与营养检查调查（NHANES）的数据进行了细致分析。系统收集了截至2019年12月31日的死亡数据。对一个由8732名参与者组成的综合群体进行了审查，随后根据基线HRR水平的四分位数将其分为四个不同的组：Q1（n = 2183）、Q2（n = 2181）、Q3（n = 2185）和Q4（n = 2183）。通过生存曲线和Cox比例风险回归模型研究HRR与CVD相关死亡率之间的相关性，后者根据NHANES的建议纳入了权重。
在研究队列的8732名参与者中，710例被确定为CVD相关死亡。Kaplan-Meier分析显示出显著关联，表明HRR降低与CVD患者生存率降低相关。单变量和多变量Cox比例风险回归分析均一致表明，与HRR较高的患者相比，HRR较低的患者CVD相关死亡风险显著升高。值得注意的是，HRR与降低CVD相关死亡率之间的相关性被认为是非线性的。
在糖尿病患者中，HRR降低与CVD相关死亡风险增加有关。
