Abdul-Rahman Farah, Xavier Joao
Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.
MicroPubl Biol. 2024 Oct 8;2024. doi: 10.17912/micropub.biology.001326. eCollection 2024.
Division of labor, the specialization of subsets of individuals in complementary tasks, increases population efficiency and fitness. We explored swarming motility in quorum sensing mutants as a model for studying the division of labor. Deletion of the signal synthesis genes or disrupts swarming, but co-culturing and restores it in a density-dependent manner. This indicates a successful division of labor where produces the signal necessary for the mutant, and the reciprocates. We used RNA sequencing to identify additional genes potentially involved in division of labor. Our findings underscore swarming as a tractable bacterial model for the division of labor among cells-a hallmark of differentiated multicellularity.
分工，即个体子集在互补任务中的专业化，提高了群体效率和适应性。我们研究了群体感应突变体中的群体游动性，以此作为研究分工的模型。信号合成基因的缺失或会破坏群体游动性，但将和共同培养能以密度依赖的方式恢复群体游动性。这表明分工成功，即产生突变体所需的信号，而则予以回应。我们使用RNA测序来鉴定可能参与分工的其他基因。我们的发现强调了群体游动性是细胞间分工的一个易于处理的细菌模型，这是分化多细胞性的一个标志。
