Berry M P, Jenkin R D, Harwood A R, Cummings B J, Quirt I C, Sonley M J, Rider W D
Int J Radiat Oncol Biol Phys. 1986 Jan;12(1):19-24. doi: 10.1016/0360-3016(86)90410-4.
The results of a pilot study using adjuvant chemotherapy and sequential half-body irradiation (HBI) for nonmetastatic Ewing's sarcoma are presented. Seventeen patients received Cyclophosphamide, Vincristine, and Adriamycin (8 cycles), followed by sequential radiation treatment of the upper (500 cGy) and lower (600 cGy) half body. Survival at 3 years was 49%. These results are contrasted with those for 18 concurrently treated patients who received standard adjuvant therapy. Overall 5-year survival and relapse-free survival for these 35 consecutive patients was 61 and 53%. The pilot protocol was given on an out-patient basis with limited and acceptable acute toxicology. Further study is necessary to determine the value of the pilot protocol.
本文介绍了一项针对非转移性尤因肉瘤使用辅助化疗和序贯半身照射（HBI）的初步研究结果。17名患者接受了环磷酰胺、长春新碱和阿霉素（8个周期）治疗，随后依次对身体上半身（500 cGy）和下半身（600 cGy）进行放射治疗。3年生存率为49%。这些结果与18名接受标准辅助治疗的同期治疗患者的结果进行了对比。这35例连续患者的总体5年生存率和无复发生存率分别为61%和53%。初步方案在门诊实施，急性毒理学反应有限且可接受。有必要进一步研究以确定初步方案的价值。
