基因多态性增加中国女孩患肾母细胞瘤的风险。
gene polymorphisms increase Wilms tumor risk in Chinese girls.
作者信息
Deng Changmi, Han Yufeng, Zhou Haixia, Zhang Jiao, Cheng Jiwen, Li Suhong, Ruan Jichen, Liu Guochang, He Jing, Hua Rui-Xi, Fu Wen
机构信息
Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
Department of Hematology, The Key Laboratory of Pediatric Hematology and Oncology Diseases of Wenzhou, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China.
出版信息
J Cancer. 2024 Oct 7;15(18):6103-6109. doi: 10.7150/jca.99928. eCollection 2024.
Wilms tumor is a prevalent pediatric tumor influenced by various genetic factors. mA modification is a common nucleotide modification that plays a role in a variety of cancers. As a "reader", YTHDF3 is essential for recognizing mA modifications. However, the association between gene polymorphisms and Wilms tumor susceptibility has not been previously reported. A five-center case‒control study including 414 patients and 1199 controls was conducted to explore the relationship between gene polymorphisms and Wilms tumor susceptibility. The samples were genotyped via TaqMan real-time quantitative polymerase chain reaction. Odds ratios (ORs) and 95% confidence intervals (CIs) were utilized as indicators to assess their correlation. The rs2241753 AA genotype was significantly associated with an increased risk of Wilms tumor in females (adjusted OR=1.74, 95% CI=1.05-2.88, =0.033). The risk of Wilms tumor was also notably elevated in female children with 1-3 risk genotypes (adjusted OR=1.47, 95% CI=1.04-2.07, =0.028). The rs2241753 AA genotype and the presence of 1-3 risk genotypes were significantly associated with increased Wilms tumor risk in female children.
肾母细胞瘤是一种受多种遗传因素影响的常见儿科肿瘤。N⁶-甲基腺嘌呤（mA）修饰是一种常见的核苷酸修饰，在多种癌症中发挥作用。作为一种“读取器”，YTHDF3对于识别mA修饰至关重要。然而，此前尚未有基因多态性与肾母细胞瘤易感性之间关联的报道。开展了一项包含414例患者和1199例对照的五中心病例对照研究，以探索基因多态性与肾母细胞瘤易感性之间的关系。通过TaqMan实时定量聚合酶链反应对样本进行基因分型。比值比（OR）和95%置信区间（CI）用作评估它们相关性的指标。rs2241753的AA基因型与女性肾母细胞瘤风险增加显著相关（调整后OR = 1.74，95% CI = 1.05 - 2.88，P = 0.033）。具有1 - 3种风险基因型的女童患肾母细胞瘤的风险也显著升高（调整后OR = 1.47，95% CI = 1.04 - 2.07，P = 0.028）。rs2241753的AA基因型和1 - 3种风险基因型的存在与女童肾母细胞瘤风险增加显著相关。
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