Zhang Hao, Liu Hao, Liu Xiaohui, Song Aiguo, Jiang Hui, Wang Xuemei
State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, 210096, China.
School of Instrument Science and Engineering, Southeast University, Nanjing, 210023, China.
Adv Healthc Mater. 2025 Jan;14(1):e2402285. doi: 10.1002/adhm.202402285. Epub 2024 Oct 23.
Carbon dots (CDs) with intrinsic bioactivities are candidates for bioimaging and disease therapy due to their diverse bioactivities, high biocompatibility, and multiple functionalities in multimodal theranostics. It is a multidisciplinary research hotspot that includes biology, physics, materials science, and chemistry. This progress report discusses the CDs with intrinsic bioactivities and their applications in multimodal theranostics. The relationship between the synthesis and structure of CDs is summarized and analyzed from a material and chemical perspective. The bioactivities of CDs including anti-tumor, antibacterial, anti-inflammatory etc. are discussed from biological points of view. Subsequently, the optical and electronic properties of CDs that can be applied in the biomedical field are summarized from a physical perspective. Based on the functional review of CDs, their applications in the biomedical field are reviewed, including optical diagnosis and treatment, biological activity, etc. Unlike previous reviews, this review combines multiple disciplines to gain a more comprehensive understanding of the mechanisms, functions, and applications of CDs with intrinsic bioactivities.
具有内在生物活性的碳点由于其多样的生物活性、高生物相容性以及在多模态诊疗中的多种功能，成为生物成像和疾病治疗的候选材料。这是一个涵盖生物学、物理学、材料科学和化学的多学科研究热点。本进展报告讨论了具有内在生物活性的碳点及其在多模态诊疗中的应用。从材料和化学角度总结并分析了碳点的合成与结构之间的关系。从生物学角度讨论了碳点的生物活性，包括抗肿瘤、抗菌、抗炎等。随后，从物理学角度总结了可应用于生物医学领域的碳点的光学和电子性质。基于对碳点的功能综述，对其在生物医学领域的应用进行了综述，包括光学诊断与治疗、生物活性等。与以往的综述不同，本综述结合了多个学科，以更全面地了解具有内在生物活性的碳点的作用机制、功能和应用。
