Mensi Asma, Medhioub Amel, Trad Nouha, Bel Haj Mabrouk Emna, Said Yosra, Debbeche Radhouane
Gastroenterology Department, Charles Nicolle Hospital. Faculty of Medicine of Tunis, Tunis-Manar University, Tunis, Tunisia.
Tunis Med. 2024 Oct 5;102(10):635-640. doi: 10.62438/tunismed.v102i10.5168.
Esophageal variceal bleeding (EVB) is one of the main causes of mortality and morbidity in cirrhotic patients. Non-invasive tests (NIT) of liver fibrosis have been developed to predict the presence of esophageal varices (EV).
To evaluate the performance of NIT of liver fibrosis such as liver transient elastography (TE) and serum scores in predicting EV.
We conducted a retrospective collecting patients with chronic liver disease. TE and serum scores were evaluated for all patients and correlated with endoscopic data.
One hundred and fifty patients were included with an average age of 58.98 years and a sex ratio of 0.68. Sixty-seven patients were cirrhotic. Viral origin C was found in 72% of cases. Thirty-three patients had EV. NIT of liver fibrosis such as TE and serum scores were statistically correlated to the presence of EV. TE had the better performance for the prediction of EV with a Cut-off of 13.5 Kpa and AUC of 0.855. In multivariate analysis, TE, AST to ALT ratio and platelet count were independent predictors of EV.
The performance of TE and serum scores in the diagnosis of EV and LEV was demonstrated. These results suggest that NIT of liver fibrosis make it possible to select patients who are candidates for gastroscopy.
食管静脉曲张破裂出血（EVB）是肝硬化患者死亡和发病的主要原因之一。已经开发出肝纤维化的非侵入性检测方法（NIT）来预测食管静脉曲张（EV）的存在。
评估肝纤维化的非侵入性检测方法，如肝脏瞬时弹性成像（TE）和血清评分在预测EV方面的性能。
我们进行了一项回顾性研究，收集慢性肝病患者。对所有患者评估TE和血清评分，并与内镜检查数据进行关联。
纳入150例患者，平均年龄58.98岁，性别比为0.68。67例患者为肝硬化。72%的病例病因是丙型病毒性肝炎。33例患者有EV。肝纤维化的非侵入性检测方法，如TE和血清评分与EV的存在具有统计学相关性。TE对EV的预测性能更好，截断值为13.5千帕，曲线下面积为0.855。在多变量分析中，TE、谷草转氨酶与谷丙转氨酶比值和血小板计数是EV的独立预测因素。
证明了TE和血清评分在诊断EV和大EV方面的性能。这些结果表明，肝纤维化的非侵入性检测方法能够筛选出适合进行胃镜检查的患者。
