1Petrovsky National Research Center of Surgery, 119435, Moscow; 2Chazov National Medical Research Center of Cardiology, 121552, Moscow, Russia.
1Petrovsky National Research Center of Surgery, 119435, Moscow; 2Chazov National Medical Research Center of Cardiology, 121552, Moscow; 3Institute of General Pathology and Pathophysiology, 125315, Moscow, Russia.
Georgian Med News. 2024 Jul-Aug(352-353):14-17.
In recent years, the prevalence of thoracic aortic aneurysm has increased, and in most cases this pathological condition is diagnosed accidentally. The aim of the current study was to determine the relationship of clinical, laboratory and morphological data with the presence of aorta wall dissection in patients with thoracic aortic aneurysm to reveal factors associated with aorta dissection.
The following data of 109 patients mean aged of 53 years with thoracic aortic aneurysm (43 patients with aortic dissection) were analyzed: presence/absence of arterial hypertension, indicators of general blood analysis and blood biochemistry, immunomorphological characteristics of the expression of Von Willebrand factor.
Statistically significant differences were found between the incidence of arterial hypertension with respect to the presence or absence of aortic dissection (p=0.002), the relationship between the content of lymphocytes (p=0.021), segmented neutrophils (p=0.001) and the presence of Von Willebrand factor in the medial layer of the aorta, i.e., the prevalence of vasa vasorum (p=0.018), with aortic dissection. The average expression area of Willebrand factor in the medial layer of the aorta during dissection was 3.6 (1.5)%, and in patients without aortic dissection - 0.8 (0.3)%.
The results of the study indicate that aortic dissection in patients with thoracic aortic aneurysm is associated with high blood pressure and is accompanied by the development of an inflammatory reaction.
近年来，胸主动脉瘤的患病率有所增加，而在大多数情况下，这种病理状况是偶然诊断出来的。本研究的目的是确定临床、实验室和形态学数据与胸主动脉瘤患者主动脉壁夹层的存在之间的关系，以揭示与主动脉夹层相关的因素。
分析了 109 名年龄 53 岁的胸主动脉瘤患者（43 名主动脉夹层患者）的以下数据：是否存在动脉高血压、一般血液分析和血液生化指标、Von Willebrand 因子表达的免疫形态学特征。
在是否存在主动脉夹层方面，动脉高血压的发生率存在统计学显著差异（p=0.002），淋巴细胞含量（p=0.021）、分叶核中性粒细胞（p=0.001）与主动脉中层 Von Willebrand 因子的关系，即脉管系统的发生率（p=0.018），与主动脉夹层有关。在夹层过程中，主动脉中层 Von Willebrand 因子的平均表达面积为 3.6（1.5）%，而在无主动脉夹层的患者中为 0.8（0.3）%。
研究结果表明，胸主动脉瘤患者的主动脉夹层与高血压有关，并伴有炎症反应的发展。
