Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, P. R. China.
Department of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, P. R. China.
PLoS One. 2024 Oct 23;19(10):e0311619. doi: 10.1371/journal.pone.0311619. eCollection 2024.
Obesity is a common public health issue worldwide, and its negative impact on lung function has garnered widespread attention. This study sought to investigate the possible association between a new obesity metric, the weight-adjusted waist index (WWI), and lung functions, providing a basis for the monitoring and protection of lung functions. We conducted a cross-sectional evaluation, analyzing data from adults in the U.S. gathered through the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2012. To explore the correlation between WWIs and lung functions, we utilized a multivariate logistic regression model with appropriate weighting to ensure accuracy. Smooth curve fitting also helped to confirm the linear nature of this relationship. Subgroup analyses were conducted to confirm the uniformity and dependability of the results. Our study included data from 13,805 adults in the United States. Multivariate linear regression analysis revealed that, in the fully adjusted model, higher WWIs were negatively correlated with forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC, peak expiratory flow rate (PEF), and forced expiratory flow rate (FEF) 25%-75% (β = -0.63; 95% confidence interval [CI] [-0.71, -0.55]; β = -0.55; 95% CI [-0.62, -0.48]; β = -0.02; 95% CI [-0.03, -0.01]; β = -1.44; 95% CI [-1.65, -1.23]; β = -0.52; 95% CI [-0.65, -0.39], respectively). Additionally, when analyzing the WWI as a categorical variable, a significant downward trend in the FVC, FEV1, PEF, and FEF 25%-75% was observed from Q2 to Q4 as the WWI increased (trend P < 0.05). Subgroup analysis showed stronger associations between WWI and lung functions, particularly among younger, non-Hispanic white, male participants, and current smokers. Our results indicate that elevated WWI is strongly associated with declining lung functions, demonstrating the importance of long-term monitoring and tracking of WWIs.
肥胖是全球普遍存在的公共卫生问题，其对肺功能的负面影响已引起广泛关注。本研究旨在探讨一种新的肥胖度量指标——体重调整腰围指数（weight-adjusted waist index，WWI）与肺功能之间可能存在的关联，为肺功能的监测和保护提供依据。我们进行了一项横断面研究，分析了 2007 年至 2012 年期间通过美国国家健康和营养检查调查（National Health and Nutrition Examination Survey，NHANES）收集的美国成年人的数据。为了探讨 WWI 与肺功能之间的相关性，我们使用了具有适当权重的多变量逻辑回归模型进行分析，以确保结果的准确性。平滑曲线拟合也有助于确认这种关系的线性性质。我们还进行了亚组分析，以确认结果的一致性和可靠性。本研究共纳入了 13805 名美国成年人的数据。多变量线性回归分析结果显示，在完全调整模型中，较高的 WWI 与用力肺活量（forced vital capacity，FVC）、第一秒用力呼气量（forced expiratory volume in the first second，FEV1）、FEV1/FVC、呼气峰流速（peak expiratory flow rate，PEF）和用力呼出 25%~75%肺活量时的平均流速（forced expiratory flow rate 25%-75%，FEF 25%-75%）呈负相关（β=-0.63；95%置信区间 [confidence interval，CI]：[-0.71，-0.55]；β=-0.55；95%CI：[-0.62，-0.48]；β=-0.02；95%CI：[-0.03，-0.01]；β=-1.44；95%CI：[-1.65，-1.23]；β=-0.52；95%CI：[-0.65，-0.39]）。此外，当将 WWI 作为分类变量进行分析时，随着 WWI 的增加（趋势 P<0.05），从 Q2 到 Q4，FVC、FEV1、PEF 和 FEF 25%-75%的显著下降趋势表明二者之间存在显著关联。亚组分析结果表明，在年龄较轻、非西班牙裔白人、男性和当前吸烟者中，WWI 与肺功能之间的关联更为强烈。我们的研究结果表明，较高的 WWI 与肺功能下降密切相关，这强调了长期监测和跟踪 WWI 的重要性。
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