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妊娠期未察觉的高血糖对母婴结局的影响。

The Impact of Undetected Hyperglycaemia During Pregnancy on Maternal and Neonatal Outcomes.

机构信息

Department of Perinatology, I Division of Gynecology and Obstetrics, Medical University of Lodz, Poland.

Department of Perinatology, Medical University of Lodz, Poland.

出版信息

J Mother Child. 2024 Oct 23;28(1):87-93. doi: 10.34763/jmotherandchild.20242801.d-24-00004. eCollection 2024 Feb 1.

DOI:10.34763/jmotherandchild.20242801.d-24-00004
PMID:39442072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11498931/
Abstract

BACKGROUND

Despite clear diagnostic criteria for hyperglycaemia first detected in pregnancy, many pregnant women do not have the proper diagnosis. The following paper analyses the course of the perinatal period in pregnant women with undetected hyperglycaemia and their newborns.

MATERIALS AND METHODS

Medical data of patients hospitalized in the Department of Perinatology between 2020 and 2022 was verified: 1st group: 40 patients with undetected hyperglycaemia, 2nd group: 40 with the diagnosis of gestational diabetes during pregnancy and adequate therapeutic management. The course of the perinatal period, abnormalities in the oral glucose tolerance test (OGTT) and the compliance with recommended postpartum tests were analysed.

RESULTS

There were significant differences in the newborn weights (p=0.039) - in the 1st group 15% large for gestational age (LGA) vs. 0% in the 2nd, and the occurrence of neonatal hyperbilirubinemia requiring phototherapy (p=0.007) - 22.5% in the 1 group vs. 2.5% in the 2. The most common mistake in the OGTT was evaluation of fasting plasma glucose. In the 1 group, no effect on incidence of hypertensive disorders, time or the route of delivery was observed. 75% from the 1 group and 36% from the 2 did not perform postpartum OGTT (p=0.003).

CONCLUSION

Hyperglycaemia in pregnancy is often undetected, which has a negative impact, especially on the neonates. In our study, LGA and hyperbilirubinaemia were significantly more common in neonates of mothers with undetected hyperglycaemia. These women had significantly more careless attitude to the postpartum diagnostic, which may influence future health and course of subsequent pregnancies. New and more effective methods of educating practitioners need to be implemented.

摘要

背景

尽管有明确的妊娠期间首次发现高血糖的诊断标准,但许多孕妇并未得到正确诊断。本文分析了未被检出的高血糖孕妇及其新生儿的围产期过程。

材料与方法

验证了 2020 年至 2022 年期间在围产医学科住院的患者的医疗数据:第 1 组:40 例未被检出的高血糖患者;第 2 组:40 例在怀孕期间被诊断为妊娠糖尿病且接受了适当治疗的患者。分析了围产期过程、口服葡萄糖耐量试验(OGTT)异常和对推荐的产后检查的依从性。

结果

新生儿体重存在显著差异(p=0.039)-第 1 组 15%为巨大儿(LGA),而第 2 组为 0%;新生儿高胆红素血症需要光疗的发生率(p=0.007)-第 1 组为 22.5%,第 2 组为 2.5%。OGTT 最常见的错误是评估空腹血糖。在第 1 组中,未观察到对高血压疾病的发生率、分娩时间或分娩方式产生影响。第 1 组中有 75%和第 2 组中有 36%的患者未进行产后 OGTT(p=0.003)。

结论

妊娠期间的高血糖常常未被检出,这对新生儿有负面影响。在我们的研究中,未被检出的高血糖孕妇的新生儿中 LGA 和高胆红素血症更为常见。这些女性对产后诊断的态度明显更为粗心,这可能会影响未来的健康和随后妊娠的过程。需要实施新的、更有效的教育医生的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11498931/fc30dc574875/j_jmotherandchild.20242801.d-24-00004_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11498931/fc30dc574875/j_jmotherandchild.20242801.d-24-00004_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11498931/fc30dc574875/j_jmotherandchild.20242801.d-24-00004_fig_001.jpg

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PLoS One. 2023 Mar 9;18(3):e0282895. doi: 10.1371/journal.pone.0282895. eCollection 2023.
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Practices and barriers to screening for hyperglycaemia in pregnancy among providers of antenatal care in Jos, Nigeria.尼日利亚乔斯市产前护理提供者对孕期高血糖筛查的实践与障碍
Afr J Lab Med. 2022 Oct 31;11(1):1845. doi: 10.4102/ajlm.v11i1.1845. eCollection 2022.
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Association between neonatal hyperbilirubinemia and hypoglycemia in Chinese women with diabetes in pregnancy and influence factors.
中国妊娠糖尿病女性新生儿高胆红素血症与低血糖的相关性及影响因素。
Sci Rep. 2022 Oct 10;12(1):16975. doi: 10.1038/s41598-022-21114-6.
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Management of validation of HPLC method for determination of acetylsalicylic acid impurities in a new pharmaceutical product.高效液相色谱法测定新型药物中乙酰水杨酸杂质的验证管理。
Sci Rep. 2022 Jan 6;12(1):1. doi: 10.1038/s41598-021-99269-x.
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The Effect of Mild Gestational Diabetes Mellitus Treatment on Adverse Pregnancy Outcomes: A Systemic Review and Meta-Analysis.轻度妊娠期糖尿病治疗对不良妊娠结局的影响:系统评价和荟萃分析。
Front Endocrinol (Lausanne). 2021 Mar 26;12:640004. doi: 10.3389/fendo.2021.640004. eCollection 2021.
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