Department of gynaecology and obstetrics, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), 120 Longshan Road, Yubei District, Chongqing, 400021, China.
Nursing Department, School of Health Sciences, Wuhan University, No. 115, Dong Hu Road, Wuhan, 430071, Hubei, China.
Sci Rep. 2022 Oct 10;12(1):16975. doi: 10.1038/s41598-022-21114-6.
This retrospective study aimed to investigate the correlation between neonatal hyperbilirubinemia (NHB) and hypoglycemia (NH) in Chinese women with diabetes in pregnancy (DIP), and the influencing factors. All the data were collected July 1, 2017 and June 30, 2020, and 10,558 Chinese women with DIP and live births were included. Two separate multivariate binary stepwise forward logistic regression analysis calculated OR with 95% CI. The prevalence rates of NHB and NH was respectively 3.65% and 5.82% among women with DIP. The comorbidity of both diseases was 0.59%. NH were 1.81 times (OR 1.81, 1.19-2.76) more likely to have hyperbilirubinemia. NHB is positively correlated with NH (OR 1.93, 1.27-2.92). Increased gestational age has a protective effect on both NH (OR 0.76, 0.68-0.85) and NHB (OR 0.80, 0.69-0.92). Abnormal placental morphology is related to NH (OR 1.55, 1.16-2.08) and NHB (OR 1.64, 1.10-2.45). Regarding neonatal outcomes, congenital heart disease (CHD) (OR 2.16, 1.25-3.73; and OR 10.14, 6.47-15.90) was a risk factor for NH and NHB. NHB and NH were significantly correlated in women with DIP. The offspring of DIP with multiple risk factors have a significantly increased risk of neonatal hyperbilirubinemia.
本回顾性研究旨在探讨中国妊娠糖尿病（DIP）妇女中新生儿高胆红素血症（NHB）与低血糖（NH）的相关性及其影响因素。所有数据均于 2017 年 7 月 1 日至 2020 年 6 月 30 日收集，纳入 10558 例 DIP 活产妇女。采用两独立变量多元逐步向前逻辑回归分析计算 OR 及其 95%CI。DIP 妇女中 NHB 和 NH 的患病率分别为 3.65%和 5.82%。两种疾病的合并患病率为 0.59%。NH 患高胆红素血症的可能性是前者的 1.81 倍（OR 1.81，1.19-2.76）。NHB 与 NH 呈正相关（OR 1.93，1.27-2.92）。胎龄增加对 NH（OR 0.76，0.68-0.85）和 NHB（OR 0.80，0.69-0.92）均有保护作用。异常胎盘形态与 NH（OR 1.55，1.16-2.08）和 NHB（OR 1.64，1.10-2.45）有关。就新生儿结局而言，先天性心脏病（CHD）（OR 2.16，1.25-3.73；OR 10.14，6.47-15.90）是 NH 和 NHB 的危险因素。DIP 妇女中 NHB 和 NH 显著相关。DIP 合并多种危险因素的新生儿发生新生儿高胆红素血症的风险显著增加。
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