Department of Mechanics, Kunming University of Science and Technology, Kunming 650500, PR China..
Department of Mechanics, Kunming University of Science and Technology, Kunming 650500, PR China.
Comput Methods Programs Biomed. 2024 Dec;257:108468. doi: 10.1016/j.cmpb.2024.108468. Epub 2024 Oct 18.
It is an indisputable physiological phenomenon that the arterial axial pre-stretch ratio (AAPSR) decreases with age, but little attention has been paid to the effect of this reduction on chronic diseases during aging.
Here we reported an experimental method to simulate arteries aging, developed a fluid-structure interaction model with the effect of AAPSR changes, and compared it with the anatomy data and structural parameters of the human thoracic aorta.
We showed that with the process of aging, the decrease of AAPSR leads to a decline of arterial elasticity, a decrease of arterial elastic strain energy, which weakens the ability to promote blood circulation, the corresponding decrease in cardiac output (CO) and cerebral blood flow (CBF) causes distal organ and body tissue ischemia, which is one of the main causes of increased blood pressure and decreased cerebral perfusion in the elderly.
Thus, reduced AAPSR is the one of main manifestation of arteries aging and has an important impact on hypertension and hypoperfusion of the brain in the process of human aging. The research contributes to a better understanding of the physiological and pathological mechanisms of aging-related diseases.
动脉轴向预拉伸比（AAPSR）随年龄增长而降低，这是一个不可否认的生理现象，但在衰老过程中，人们对这种降低对慢性疾病的影响关注甚少。
我们在此报告了一种模拟动脉老化的实验方法，开发了一个考虑 AAPSR 变化影响的流固耦合模型，并将其与人体胸主动脉的解剖数据和结构参数进行了比较。
我们表明，随着老化过程的进行，AAPSR 的降低导致动脉弹性下降，动脉弹性应变能减少，从而削弱了促进血液循环的能力，相应的每搏输出量（CO）和脑血流量（CBF）减少导致远端器官和身体组织缺血，这是老年人血压升高和脑灌注减少的主要原因之一。
因此，AAPSR 的降低是动脉老化的主要表现之一，对人类衰老过程中高血压和脑灌注不足有重要影响。该研究有助于更好地理解与衰老相关疾病的生理和病理机制。
