Centre for Ionics Universiti Malaya, Department of Physics, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia; School of Engineering, Taylor's University, 1 Jalan Taylor's, 47500, Subang Jaya, Selangor, Malaysia.
Higher Institution Centre of Excellence (HICoE), UM Power Energy Dedicated Advanced Centre (UMPEDAC), Level 4, Wisma R&D, Universiti Malaya, Jalan Pantai Baharu, 59990, Kuala Lumpur, Malaysia.
Microb Pathog. 2024 Dec;197:107059. doi: 10.1016/j.micpath.2024.107059. Epub 2024 Oct 22.
In 2020, the World Health Organization (WHO) declared a pandemic due to the emergence of the coronavirus disease (COVID-19) which had resulted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, the emergence of many new variants and mutants were found to be more harmful compared to the previous strains. As a result, research scientists around the world had devoted significant efforts to understand the mechanism, causes and transmission due to COVID-19 along with the treatment to cure these diseases. However, despite achieving several findings, much more was unknown and yet to be explored. Hence, along with these developments, it is also extremely essential to design effective systems by incorporating smart materials to battle the COVID-19. Therefore, several approaches have been implemented to combat against COVID-19. Recently, the graphene-based materials have been explored for the current COVID-19 and future pandemics due to its superior physicochemical properties, providing efficient nanoplatforms for optical and electrochemical sensing and diagnostic applications with high sensitivity and selectivity. Moreover, based on the photothermal effects or reactive oxygen species formation, the carbon-based nanomaterials have shown its potentiality for targeted antiviral drug delivery and the inhibitory effects against pathogenic viruses. Therefore, this review article sheds light on the recent progress and the most promising strategies related to graphene and related materials and its applications for detection, decontamination, diagnosis, and protection against COVID-19. In addition, the key challenges and future directives are discussed in detail for fundamental design and development of technologies based on graphene-based materials along with the demand aspects of graphene-based products and lastly, our personal opinions on the appropriate approaches to improve these technologies respectively.
2020 年,世界卫生组织(WHO)宣布冠状病毒病(COVID-19)大流行,这是由严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)引起的。目前,与之前的毒株相比,许多新的变种和突变体的出现被认为更具危害性。因此,世界各地的研究科学家投入了大量精力,研究 COVID-19 的机制、原因和传播途径,以及治疗这些疾病的方法。然而,尽管取得了一些发现,但仍有许多未知和有待探索的地方。因此,随着这些进展,设计有效的系统,结合智能材料来对抗 COVID-19 也是非常重要的。因此,已经采取了几种方法来对抗 COVID-19。最近,由于其优异的物理化学性质,基于石墨烯的材料已被用于当前的 COVID-19 和未来的大流行,为光学和电化学传感和诊断应用提供了高效的纳米平台,具有高灵敏度和选择性。此外,基于光热效应或活性氧物质的形成,碳基纳米材料已显示出其在靶向抗病毒药物输送和抑制致病病毒方面的潜力。因此,本文综述了与石墨烯及相关材料及其在 COVID-19 的检测、净化、诊断和防护方面的应用相关的最新进展和最有前途的策略。此外,还详细讨论了基于石墨烯的材料的技术的关键挑战和未来方向,以及对石墨烯基产品的需求方面,最后,我们个人对分别改进这些技术的适当方法的看法。