University of Baghdad, College of Science for Women, Department of Chemistry, Baghdad, Iraq; Bolu Abant İzzet Baysal University, Faculty of Arts and Science, Department of Chemistry Bolu, 14030, Turkiye.
Bolu Abant İzzet Baysal University, Faculty of Arts and Science, Department of Biology Bolu, 14030, Turkiye; Bolu Abant İzzet Baysal University, Faculty of Arts and Science, Department of Chemistry Bolu, 14030, Turkiye.
J Ethnopharmacol. 2025 Jan 30;337(Pt 3):118981. doi: 10.1016/j.jep.2024.118981. Epub 2024 Oct 22.
Morus alba L., mulberry, has played a significant role in providing food, medicine, and materials throughout human history. From its historical importance to its diverse cultural uses, mulberry remains a versatile and valuable resource, enriching various aspects of human life across civilizations. Mulberry exhibits ethnopharmacological applications for treating various ailments including atopic dermatitis, also known as eczema.
The objective of the study was extracting the putative active substances from white mulberry, evaluating potential of the extract in treating and reducing reliance on chemical medications by providing a chemical composition of the extract along with effect of extracts on eczema symptoms.
For testing the impact of mulberry extract on relieving eczema symptoms, white mulberry fruit extracts were prepared by butanol extraction. Water-in-oil (W/O) emulsification was used to prepare ointment. Analysis of the mulberry extract was conducted using GC-MS after additional processing of extracts. Clinical trials on 110 individuals, divided into patient-treatment, normal-treatment, and patient-placebo groups, involved applying the ointment containing 0.5% mulberry fruit extract for 4-6 weeks, with blood sample analysis before and after the trial. Blood samples were analyzed for various parameters including Granzyme B, Vit. E, TC, TG, HDL, and LDL levels. The antibacterial activity of the extract against Staphylococcus aureus was determined using involve growth curve analysis and inhibition of colony formation on LB plates. Morus alba L. name was checked from "World Flora Online" (www.worldfloraonline.org) and MPNS (mpns.kew.org) RESULTS: We monitored a noticeable enhancement in the skin ulceration after the treatment. In addition, Granzyme B, Vitamin E, TC, TG, HDL, and LDL levels were improved in the patient-treatment group closer to healthy levels, indicating potential therapeutic benefits of Morus alba extract. The extract's efficacy was also tested on S. aureus, a bacterium commonly associated with eczema. Results showed that extract obtained from white mulberry fruits has an inhibitory impact on S. aureus growth.
The findings suggest that Morus alba extract holds promise as a therapeutic intervention for atopic dermatitis, demonstrating significant improvements in key biomarkers towards levels observed in healthy individuals.
桑树（Morus alba L.），即桑树，在人类历史上一直扮演着提供食物、药物和材料的重要角色。从其历史重要性到其多样化的文化用途，桑树仍然是一种多功能且有价值的资源，丰富了不同文明人类生活的各个方面。桑树在治疗特应性皮炎（又称湿疹）等各种疾病方面具有民族药理学应用。
本研究的目的是从白桑中提取潜在的活性物质，评估提取物在治疗中的潜力，并通过提供提取物的化学成分以及提取物对湿疹症状的影响，减少对化学药物的依赖。
为了测试桑椹提取物对缓解湿疹症状的影响，通过丁醇提取法制备白桑果实提取物。采用水包油（W/O）乳化法制备软膏。对提取物进行进一步处理后，使用 GC-MS 对桑椹提取物进行分析。对 110 名个体进行临床试验，分为患者治疗组、正常治疗组和患者安慰剂组，在 4-6 周内涂抹含有 0.5%桑椹果实提取物的软膏，在试验前后进行血液样本分析。分析血液样本中的各种参数，包括颗粒酶 B、维生素 E、TC、TG、HDL 和 LDL 水平。使用生长曲线分析和在 LB 平板上抑制菌落形成来确定提取物对金黄色葡萄球菌的抗菌活性。通过检查“世界植物在线”（www.worldfloraonline.org）和 MPNS（mpns.kew.org），确定了 Morus alba L. 的名称。结果：我们监测到治疗后皮肤溃疡明显改善。此外，患者治疗组的颗粒酶 B、维生素 E、TC、TG、HDL 和 LDL 水平更接近健康水平，表明 Morus alba 提取物具有潜在的治疗益处。还对金黄色葡萄球菌进行了提取物的功效测试，金黄色葡萄球菌是一种与湿疹有关的细菌。结果表明，从白桑果实中提取的提取物对金黄色葡萄球菌的生长具有抑制作用。
研究结果表明，Morus alba 提取物有望成为特应性皮炎的治疗干预措施，在关键生物标志物方面显示出显著改善，使其接近健康个体的水平。
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