[自然杀伤（NK）细胞的研究进展与2019冠状病毒病（COVID-19）的发展]
[Research progress of natural killer (NK) cells and the development of coronavirus disease 2019 (COVID-19)].
作者信息
Chen Juan, Zhou Yongxue, Bao Shengchuan, Chen Ting, Li Jingtao, Wei Hailiang, Yan Shuguang
机构信息
College of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046; Shaanxi Provincial Key Laboratory of Gastrointestinal Diseases, Xianyang 712046, China.
Department of Infectious Disease, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China.
出版信息
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2024 Sep;40(9):839-843.
Natural killer (NK) cells play an important role in clearing viruses and performing immunomodulation, and they possess innate immunomodulatory functions and acquired immune responses through secreting chemokines and acting in synergy with other natural immune cells. With in-depth studies of coronavirus disease 2019 (COVID-19) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, NK cells have been identified as playing an important role. SARS-CoV-2 infection affects the distribution and effector function of NK cells, and the immune response of NK cells may influence the prognosis of patients with COVID-19. This review summarizes the latest research on the role of NK cells in COVID-19 infection, and discusses their potential as therapeutic agents, aiming to provide insights into the prevention of immune damage caused by SARS-CoV-2.
自然杀伤（NK）细胞在清除病毒和进行免疫调节方面发挥着重要作用，它们通过分泌趋化因子并与其他天然免疫细胞协同作用，具有先天免疫调节功能和获得性免疫反应。随着对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染所致2019冠状病毒病（COVID-19）研究的深入，NK细胞已被确定发挥重要作用。SARS-CoV-2感染会影响NK细胞的分布和效应功能，而NK细胞的免疫反应可能会影响COVID-19患者的预后。本综述总结了关于NK细胞在COVID-19感染中作用的最新研究，并讨论了它们作为治疗剂的潜力，旨在为预防SARS-CoV-2引起的免疫损伤提供见解。
Zotero 插件