Department of Anesthesiology, University of California San Diego, 9400 Campus Point Drive, San Diego, CA 92037, USA.
Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA.
Adv Anesth. 2024 Dec;42(1):85-96. doi: 10.1016/j.aan.2024.07.007. Epub 2024 Sep 6.
Consistent evidence supporting the use of cannabinoids for management of acute pain is lacking. A small number of observational studies suggest cannabinoid use is associated with reduced opioid use but pain scores remain unchanged. The majority of randomized trials involving a variety of cannabinoid compounds have shown no benefit for acute pain. Chronic cannabis users may be at increased risk of experiencing elevated levels of acute pain and these individuals may require greater quantities of opioids compared to non-cannabis users. There is also evidence suggesting that chronic, high-dose cannabis users may be at increased risk of perioperative cardiovascular complications.
目前缺乏支持使用大麻素治疗急性疼痛的一致性证据。少数观察性研究表明，大麻素的使用与减少阿片类药物的使用有关，但疼痛评分保持不变。大多数涉及各种大麻素化合物的随机试验都没有显示出对急性疼痛的益处。慢性大麻使用者可能面临更高水平的急性疼痛风险，与非大麻使用者相比，这些人可能需要更多的阿片类药物。还有证据表明，慢性、高剂量大麻使用者可能面临围手术期心血管并发症风险增加的风险。
