de Oliveira Frederice R, Pereira A A L, Arruda G V, Gouveia A G, de Andrade F E M, Mori L J, Linck R D M, Shimada A K, Hanna S A, de Moraes F Y, Marta G N
Department of Breast Surgery, Hospital Sírio-Libanês, Brazil.
Department of Clinical Oncology, Hospital Sírio-Libanês, Brasilia, Brazil.
Clin Oncol (R Coll Radiol). 2025 Feb;38:103650. doi: 10.1016/j.clon.2024.10.002. Epub 2024 Oct 5.
This study evaluated the clinicopathological characteristics, treatment trends, and overall survival (OS) in male breast cancer (BC) in Sao Paulo State of Brazil.
Men diagnosed with invasive breast cancer between January 2000 and June 2020 were identified from Fundação Oncocentro de Sao Paulo database encompasses data pertinent to 46 million residents of the Sao Paulo State of Brazil. Patients were described according to age, education level, clinical stage, treatment modalities, and medical practice. Categorical variables were described as percentages and frequencies. Demographic, treatment factors, and OS were associated using a Cox proportional hazard regression model while accounting for different lengths of participant follow-up. The Kaplan-Meier curves were used to display survival curves.
A total of 907 male BC patients were included. The age distribution at diagnosis was <51 years, 51-70 years, and >70 years in 21.5%, 51.5% and 27.0% of patients, respectively. The proportions of stages I, II, III, and IV were 19.5%, 36.6%, 31.5%, and 12.3%. For each stage I, II, III, and IV, 5- and 10-years OS were 87.9% and 77.8%, 79.9% and 58.9%, 51.6% and 24.5%, 20.0% and 5.6%, respectively. Patients who received postoperative radiotherapy experienced a significant improvement in OS (HR 0.67; 95% CI 0.53-0.84; p < 0.001). In the multivariable analysis adjusted for practice (public or private), education (low or medium/high), age, stage at diagnosis, and treatment modalities, the significant independent predictor for OS was stage at diagnosis.
Male BC tends to be diagnosed at a more advanced stage and older age at the time of diagnosis. Age and educational level did not influence survival outcomes. Stage at diagnosis and the use of postoperative radiotherapy were factors associated with improved OS.
本研究评估了巴西圣保罗州男性乳腺癌（BC）的临床病理特征、治疗趋势及总生存期（OS）。
从圣保罗肿瘤中心基金会数据库中识别出2000年1月至2020年6月期间被诊断为浸润性乳腺癌的男性患者，该数据库涵盖了巴西圣保罗州4600万居民的相关数据。根据年龄、教育水平、临床分期、治疗方式和医疗实践对患者进行描述。分类变量以百分比和频率表示。在考虑参与者不同随访时长的情况下，使用Cox比例风险回归模型分析人口统计学、治疗因素和总生存期之间的相关性。采用Kaplan-Meier曲线展示生存曲线。
共纳入907例男性乳腺癌患者。诊断时的年龄分布为：年龄<51岁的患者占21.5%，51 - 70岁的患者占51.5%，>70岁的患者占27.0%。I期、II期、III期和IV期的比例分别为19.5%、36.6%、31.5%和12.3%。对于I期、II期、III期和IV期的患者，5年和10年总生存期分别为87.9%和77.8%、79.9%和58.9%、51.6%和24.5%、20.0%和5.6%。接受术后放疗的患者总生存期有显著改善（风险比[HR] 0.67；95%置信区间[CI] 0.53 - 0.84；p < 0.001）。在对医疗实践（公立或私立）、教育水平（低或中/高）、年龄、诊断分期和治疗方式进行校正的多变量分析中，总生存期的显著独立预测因素是诊断分期。
男性乳腺癌在诊断时往往处于更晚期且年龄较大。年龄和教育水平不影响生存结果。诊断分期和术后放疗的使用是与总生存期改善相关的因素。
