Hu Meng, Wang Yongchong, Zhu Wen, Chen Xiaozhen
Department of Psychiatry, The Affiliated People's Hospital of Ningbo University, 251 Baizhang East Road, Ningbo City, 315000, Zhejiang Province, China.
Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo, 315000, Zhejiang, China.
Clin Exp Nephrol. 2025 Mar;29(3):301-315. doi: 10.1007/s10157-024-02575-7. Epub 2024 Oct 23.
Irregular sleep duration has been linked with systemic diseases as well as chronic kidney disease (CKD). However, most of the evidence is low-quality and from cross-sectional data. We hereby present a meta-analysis of cohort studies examining the longitudinal association between short and long sleep with the risk of CKD or proteinuria.
Databases of Embase, PubMed, CENTRAL, Web of Science, and Scopus were searched up to 5th April 2024. The risk of CKD/proteinuria was assessed with short or long sleep duration.
Nine studies were included. Both short and long sleep duration were associated with a mild increase in the risk of CKD/proteinuria. Based on different cutoffs for short sleep, we noted that sleep of ≤ 7 h was not associated with a significantly increased risk of CKD/proteinuria. A mild significant risk was noted in the subgroup of ≤ 6 h while a significant association was noted for sleep ≤ 5 h. For longer sleep duration, individuals with ≥ 8 h of sleep had an increased risk of CKD/proteinuria. However, the results were non-significant for individuals with ≥ 9 h of sleep. Non-significant results were noted for separate analyses on male, female, high body mass index, and elderly (≥ 60 years) individuals.
Both short and long sleep durations are associated with a significant increase in the risk of CKD/proteinuria in the adult population.
睡眠时间不规律已与全身性疾病以及慢性肾脏病（CKD）相关联。然而，大多数证据质量较低且来自横断面数据。我们在此对队列研究进行荟萃分析，以检验短睡眠和长睡眠与CKD或蛋白尿风险之间的纵向关联。
截至2024年4月5日，检索了Embase、PubMed、CENTRAL、科学网和Scopus数据库。通过短睡眠或长睡眠持续时间评估CKD/蛋白尿风险。
纳入了9项研究。短睡眠和长睡眠持续时间均与CKD/蛋白尿风险轻度增加相关。基于短睡眠的不同截断值，我们注意到睡眠≤7小时与CKD/蛋白尿风险显著增加无关。在睡眠≤6小时的亚组中观察到轻度显著风险，而在睡眠≤5小时时观察到显著关联。对于较长睡眠持续时间，睡眠≥8小时的个体患CKD/蛋白尿的风险增加。然而，对于睡眠≥9小时的个体，结果不显著。对男性、女性、高体重指数个体和老年人（≥60岁）进行的单独分析结果不显著。
在成年人群中，短睡眠和长睡眠持续时间均与CKD/蛋白尿风险显著增加相关。
