Henríquez-Beltrán Mario, Benítez Iván, Belmonte Thalía, Jorquera Jorge, Jorquera-Diaz Jorge, Cigarroa Igor, Burgos Matías, Sanhueza Rocio, Jeria Claudia, Fernandez-Bussy Isabel, Nova-Lamperti Estefania, Barbé Ferrán, Targa Adriano, Labarca Gonzalo
Núcleo de Investigación en Ciencias de la Salud, Universidad Adventista de Chile, Chillán 3780000, Chile.
Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova-Santa Maria, Biomedical Research Institute of Lleida (IRBLleida), 25198 Lleida, Spain.
J Clin Med. 2023 Oct 20;12(20):6639. doi: 10.3390/jcm12206639.
Current studies agree on the impact of sleep and circadian rest-activity rhythm alterations in acute respiratory distress syndrome (ARDS) survivors. However, research on the duration of this impact is scarce. In this study, we evaluate the impact of ARDS on the sleep and circadian rest-activity rhythm of COVID-19 survivors twelve months after hospital discharge. This is a prospective study including COVID-19 survivors with and without ARDS during hospitalization. Data was collected four and twelve months after hospital discharge. The interventions included one-week wrist actigraphy and a home sleep apnea test (HSAT), and evaluations were conducted according to the Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale (ESS), and insomnia severity index (ISI). Fifty-two patients were evaluated (ARDS = 31 and non-ARDS = 21); they had a median age of 49.0 [39.0;57.2] years and 53.8% were male. After twelve months, 91.3% presented poor sleep quality, 58.7% presented insomnia, 50% presented daytime somnolence, and 37% presented comorbid insomnia and obstructive sleep apnea (COMISA). No significant improvement was observed in relation to sleep or the circadian rest-activity rhythm between four and twelve months. A tendency of poor sleep quality, insomnia, daytime somnolence, and COMISA was observed. Finally, there was no significant impact on the circadian rest-activity rhythm between four and twelve months or between the groups.
目前的研究一致认为睡眠和昼夜休息-活动节律改变对急性呼吸窘迫综合征（ARDS）幸存者有影响。然而，关于这种影响持续时间的研究却很匮乏。在本研究中，我们评估了ARDS对COVID-19幸存者出院十二个月后睡眠和昼夜休息-活动节律的影响。这是一项前瞻性研究，纳入了住院期间发生或未发生ARDS的COVID-19幸存者。在出院后四个月和十二个月收集数据。干预措施包括为期一周的手腕活动记录仪监测和家庭睡眠呼吸暂停测试（HSAT），并根据匹兹堡睡眠质量指数（PSQI）、爱泼华嗜睡量表（ESS）和失眠严重程度指数（ISI）进行评估。共评估了52例患者（ARDS组 = 31例，非ARDS组 = 21例）；他们的年龄中位数为49.0[39.0；57.2]岁，53.8%为男性。十二个月后，91.3%的患者睡眠质量差，58.7%的患者存在失眠，50%的患者有日间嗜睡，37%的患者合并失眠和阻塞性睡眠呼吸暂停（COMISA）。在四个月至十二个月期间，睡眠或昼夜休息-活动节律方面未观察到显著改善。观察到睡眠质量差、失眠、日间嗜睡和COMISA有加重趋势。最后，在四个月至十二个月期间或两组之间，昼夜休息-活动节律均未受到显著影响。
