Zhang Qi, Guo Shiyun, Wang Honggang
Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Cell Biochem Biophys. 2025 Jun;83(2):1387-1397. doi: 10.1007/s12013-024-01597-y. Epub 2024 Oct 23.
The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome consists of pro-caspase-1, NLRP3 and apoptosis-related speckle-like protein (ASC). It can detect multiple microorganisms, endogenous danger signals and environmental stimulus including adenosine triphosphate (ATP), urate, cholesterol crystals, and so on, thereby forming activated NLRP3 inflammasome. During the course of the activation of NLRP3 inflammasome, pro-caspase-1 is transformed into activated caspase-1 that results in the maturation and secretion of interleukin-1beta (IL-1β) and IL-18. The dysfunction of NLRP3 inflammasome participates in multiple diseases such as liver diseases, renal diseases, nervous system diseases and diabetes. Baicalin is the primary bioactive component of Scutellaria baicalensis, which has been used since ancient times. Baicalin has many types of biological functions, such as anti-bacterial, anti-tumor and antioxidant. More and more evidence suggests that baicalin regulation of NLRP3 inflammasome is involved in different diseases. However, the mechanism is still elusive. Here, we reviewed the progress of baicalin regulation of NLRP3 inflammasome in many kinds of diseases to lay a foundation for future researches.
含NACHT、LRR和PYD结构域蛋白3（NLRP3）炎性小体由前半胱天冬酶-1、NLRP3和凋亡相关斑点样蛋白（ASC）组成。它能检测多种微生物、内源性危险信号和环境刺激，包括三磷酸腺苷（ATP）、尿酸盐、胆固醇晶体等，从而形成活化的NLRP3炎性小体。在NLRP3炎性小体激活过程中，前半胱天冬酶-1转化为活化的半胱天冬酶-1，导致白细胞介素-1β（IL-1β）和IL-18成熟并分泌。NLRP3炎性小体功能失调参与多种疾病，如肝脏疾病、肾脏疾病、神经系统疾病和糖尿病。黄芩苷是黄芩的主要生物活性成分，自古以来就被使用。黄芩苷具有多种生物学功能，如抗菌、抗肿瘤和抗氧化。越来越多的证据表明，黄芩苷对NLRP3炎性小体的调节参与不同疾病。然而，其机制仍不清楚。在此，我们综述了黄芩苷对多种疾病中NLRP3炎性小体调节的研究进展，为未来研究奠定基础。
