Cross D E, Coxe-Gilliland R, Weaver P
Transplant Proc. 1979 Dec;11(4):1908-10.
In a series of 36 cadaver transplants, we have found that matching the DR antigens had greater value in predicting good transplant outcome than did matching the A and B antigens. A much larger series of transplants utilizing DR antigen matching will be necessary to confirm these promising results; however, it would appear that performed donor-specific BLC detected at room temperature have no relationship to subsequent transplant outcome. It is, however, important to differentiate them from weak HLA-A,B,C antibodies which have been proven to lead to accelerated rejection. We recommend that the clinical crossmatch include simultaneous B-cell-depleted and B-cell-enriched tests to avoid this problem.
在一系列36例尸体移植中，我们发现，与A和B抗原匹配相比，DR抗原匹配在预测良好的移植结果方面具有更大的价值。需要进行一系列大得多的采用DR抗原匹配的移植手术，以证实这些有前景的结果；然而，在室温下检测到的已进行的供体特异性BLC似乎与随后的移植结果无关。然而，将它们与已被证明会导致加速排斥反应的弱HLA - A、B、C抗体区分开来很重要。我们建议临床交叉配型应同时包括B细胞耗竭试验和B细胞富集试验，以避免这个问题。
