Biochemistry Department, Khyber Girls Medical College, Peshawar, Pakistan.
Biochemistry Department, Khyber Medical University, Peshawar, Pakistan.
BMC Pregnancy Childbirth. 2024 Oct 23;24(1):695. doi: 10.1186/s12884-024-06868-3.
Pregnancy is a state of increased metabolic demand, and poor maternal nutrition can exacerbate these changes, potentially increasing the risk of cardiometabolic disorders.This study is significant as it investigates the effect of high energy nutritional supplements on cardio metabolic risk markers in underweight primigravidas.
A single blinded randomized controlled trial was conducted from April 2018- August 2019 among the Pakistani tertiary care facilities of Khyber Pakhtunkhwa. A total of thirty six participants were randomized into two groups receiving either high energy nutritional supplement 'MAAMTA' or Placebo. They were instructed to take Placebo/Supplement alongside to their regular prenatal care and food from their first antenatal visit till a week postnatally. Anthropometric measurements and blood samples for biochemical parameters insulinlevels, fasting blood glucose & lipid profile were taken at baseline visit, between 16 and 20 weeks gestation and a post natal visit.
The two-way repeated measures ANOVA showed that there was a highly significant time effect on participant's Insulin level (F (1.8, 53.6) = 10.64, P < 0 0.000, ηp = 0.269). A highly significant time effect on participant's insulin resistance (F (2, 68) = 8.116,P < 0 0.001, ηp = 0.193) was also observed. There was a highly significant time effect on participant's LDL level as well (F (2, 68) = 11.82, P < 0 0.000, ηp = 0.258).
Supplementation with high energy nutritional supplements may improve insulin levels and insulin sensitivity in underweight primigravidas.
gov ClinicalTrials.gov Identifier: ISRCTN 10088578. Registered on 27 March 2018. https://www.isrctn.com/ISRCTN10088578 .
妊娠是代谢需求增加的状态，不良的母体营养会加剧这些变化，从而增加患心脏代谢疾病的风险。本研究旨在调查高能量营养补充剂对低体重初产妇心脏代谢风险标志物的影响，因此具有重要意义。
这是一项于 2018 年 4 月至 2019 年 8 月在巴基斯坦开伯尔-普赫图赫瓦省的三级保健设施中进行的单盲随机对照试验。共有 36 名参与者被随机分为两组，一组接受高能量营养补充剂“MAAMTA”，另一组接受安慰剂。从第一次产前就诊开始，参与者被要求在常规产前护理和食物的基础上，每天额外服用安慰剂/补充剂，直到产后一周。在基线访视、16-20 周妊娠期间和产后访视时，测量参与者的人体测量学指标和血液样本，用于检测胰岛素水平、空腹血糖和血脂谱等生化参数。
双向重复测量方差分析显示，参与者的胰岛素水平存在高度显著的时间效应（F（1.8，53.6）= 10.64，P < 0.000，ηp= 0.269）。参与者的胰岛素抵抗也存在高度显著的时间效应（F（2，68）= 8.116，P < 0.001，ηp= 0.193）。参与者的 LDL 水平也存在高度显著的时间效应（F（2，68）= 11.82，P < 0.000，ηp= 0.258）。
补充高能量营养补充剂可能会改善低体重初产妇的胰岛素水平和胰岛素敏感性。
https://www.clinicaltrials.gov。
ClinicalTrials.gov 标识符：ISRCTN 10088578。于 2018 年 3 月 27 日注册。https://www.isrctn.com/ISRCTN10088578。
