Department of Child Health Care, Women's Hospital of Nanjing Medical University(Nanjing Women and Children's Healthcare Hospital), Nanjing, Jiangsu, China.
Nanjing Medical Key Laboratory of Developmental Behavioral Pediatrics, Nanjing, China.
BMC Psychiatry. 2024 Oct 23;24(1):723. doi: 10.1186/s12888-024-06099-y.
It was reported that more than 96% of autism spectrum disorder (ASD) children are accompanied with different degrees of sensory processing abnormalities, and up to 50% of ASD children exhibit abnormal auditory response. Studies have confirmed that some ASD children's abnormal auditory response may be related to their abnormal auditory processing. Prior research demonstrated that ASD children's auditory processing has high heterogeneity, thus, ASD children's auditory processing may have different developmental trajectories. However, no study has concentrated on the developmental trajectories of ASD children's auditory processing. In addition, auditory processing plays a crucial role in ASD children's language development, thus, ASD children's different language development outcomes may be related to different auditory processing development tracks. Therefore, this study aims to explore the developmental trajectory of auditory processing in ASD children and analyze the relationship between different developmental trajectories of auditory processing and language impairment.
METHODS/DESIGN: In this study, 220 ASD children aging 3 years and 0 months to 4 years and 11 months are recruited as the research objects, and their demographic characteristics are collected. The subjects are tested for peripheral hearing, intelligence, and autism symptoms. Furthermore, ASD children's auditory processing and language development are evaluated at baseline, 1 year, and 2 years later. In addition, ASD children's auditory processing is evaluated by electrophysiological test and the Preschool Auditory Processing Assessment Scale. Moreover, ASD children's language skills are assessed using the Language Development Assessment Scale for Children Aged 1-6. The various categories of the developmental trajectory of ASD children's auditory processing are examined through the latent category growth model. Additionally, a hierarchical regression model is developed to analyze the predictive impact of different auditory processing development trajectories on language impairment in ASD children.
This longitudinal study will explore the categories of auditory processing developmental trajectories in ASD children, and analyze the relationship between different categories of auditory processing developmental trajectories and language development, providing new ideas and targeted targets for the rehabilitation training of language impairment in ASD children, as well as promoting early and accurate interventions for ASD children.
据报道，超过 96%的自闭症谱系障碍（ASD）儿童伴有不同程度的感觉处理异常，多达 50%的 ASD 儿童表现出异常的听觉反应。研究已经证实，一些 ASD 儿童的异常听觉反应可能与其异常的听觉处理有关。先前的研究表明，ASD 儿童的听觉处理具有高度的异质性，因此，ASD 儿童的听觉处理可能具有不同的发展轨迹。然而，目前尚无研究集中于 ASD 儿童听觉处理的发展轨迹。此外，听觉处理在 ASD 儿童的语言发展中起着至关重要的作用，因此，ASD 儿童不同的语言发展结果可能与不同的听觉处理发展轨迹有关。因此，本研究旨在探讨 ASD 儿童听觉处理的发展轨迹，并分析听觉处理不同发展轨迹与语言障碍的关系。
方法/设计：本研究纳入了 220 名年龄在 3 岁零 0 个月至 4 岁 11 个月的 ASD 儿童作为研究对象，并收集了他们的人口统计学特征。对这些儿童进行了外周听力、智力和自闭症症状测试。此外，在基线、1 年和 2 年后评估 ASD 儿童的听觉处理和语言发展情况。还通过电生理测试和学前听觉处理评估量表评估 ASD 儿童的听觉处理情况。此外，还使用儿童语言发展评估量表对 ASD 儿童的语言技能进行评估。通过潜在类别增长模型来检查 ASD 儿童听觉处理发展轨迹的各个类别。并通过分层回归模型分析不同听觉处理发展轨迹对 ASD 儿童语言障碍的预测影响。
本纵向研究将探讨 ASD 儿童听觉处理发展轨迹的类别，并分析不同类别听觉处理发展轨迹与语言发展之间的关系，为 ASD 儿童语言障碍的康复训练提供新思路和靶向目标，促进对 ASD 儿童的早期和准确干预。
