Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Coyote Bioscience Co., Ltd, Beijing, China.
Virol J. 2024 Oct 23;21(1):261. doi: 10.1186/s12985-024-02497-6.
Human Papillomavirus (HPV) DNA screening was a crucial element in the fight against cervical cancer and had been adopted in many countries, including China. However, the onset of the COVID-19 pandemic in March 2020 disrupted this program significantly.
The aim of this study is to investigate the prevalence and distribution of HPV genotypes among the population undergoing cervical cancer screening during the pandemic period. From January 2017 to December 2022, Peking Union Medical College Hospital gathered 45,496 cervical swabs from individuals undergoing cervical cancer screening. These samples were analyzed to detect fifteen high-risk HPV (HR-HPV) DNA types and a combination of two low-risk HPV (LR-HPV) types.
The study revealed an overall infection rate of 11.24% (5,114/45,496), with 11.06% (5,032/45,496) of individuals infected with HR-HPV. The number of HPV screening patients and the infection rates of HPV, HR-HPV, LR-HPV, multiple genotype HPV (M-HPV), and single genotype HPV (S-HPV) during the pandemic were lower than those observed before the pandemic. Moreover, the age group with the highest percentage of infected individuals was under 45-49 years, with HPV52, HPV58, HPV16, and HPV51 being the most prevalent genotypes. Notably, HPV66 emerged as the fifth most commonly detected genotype during the pandemic. Additionally, among the eleven age groups examined, women under 25 exhibited the highest detection rate, with HPV52 and HPV16 infection rates exceeding those observed in the pre-pandemic period.
The findings of this study offer significant insights for shaping HPV prevention strategies and enhancing cervical cancer screening initiatives in China following the epidemic.
人乳头瘤病毒（HPV）DNA 筛查是抗击宫颈癌的重要手段，已在包括中国在内的许多国家得到采用。然而，2020 年 3 月 COVID-19 大流行的爆发，极大地打乱了这一计划。
本研究旨在调查疫情期间宫颈癌筛查人群中 HPV 基因型的流行率和分布。北京协和医学院医院从 2017 年 1 月至 2022 年 12 月收集了 45496 例宫颈癌筛查个体的宫颈拭子。对这些样本进行了分析，以检测 15 种高危 HPV（HR-HPV）DNA 类型和两种低危 HPV（LR-HPV）类型的组合。
研究显示，总感染率为 11.24%（5114/45496），其中 11.06%（5032/45496）的个体感染了 HR-HPV。疫情期间 HPV 筛查患者数量和 HPV、HR-HPV、LR-HPV、多种基因型 HPV（M-HPV）和单基因型 HPV（S-HPV）的感染率均低于疫情前。此外，感染人数最多的年龄组为 45-49 岁，最常见的基因型为 HPV52、HPV58、HPV16 和 HPV51。值得注意的是，HPV66 在疫情期间成为第五种最常见的检测基因型。此外，在所检查的 11 个年龄组中，25 岁以下女性的检出率最高，HPV52 和 HPV16 的感染率高于疫情前。
本研究结果为中国疫情后制定 HPV 预防策略和加强宫颈癌筛查计划提供了重要依据。
