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病例报告:胎儿-母体出血及其与显著新生儿贫血的关联。

Case Report: Fetomaternal hemorrhage and its association with pronounced neonatal anemia.

作者信息

Li Peng, Shu Hua, Lin Peng, Wang Jishui, Zhang Di, Man Dongmei, Wang Fengge

机构信息

College of Clinical Medicine, Jining Medical University, Jining, Shandong, China.

Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.

出版信息

Front Pediatr. 2024 Oct 8;12:1423786. doi: 10.3389/fped.2024.1423786. eCollection 2024.

Abstract

Fetomaternal hemorrhage (FMH) is a perplexing obstetric condition that predominantly occurs during the third trimester or at the time of delivery. Its insidious and non-specific onset often leads to diagnostic challenges. The underlying pathophysiology of FMH remains incompletely understood, though it is primarily attributed to compromise of the placental barrier. The severity of the condition is intrinsically associated with the volumn of blood loss, the hemorrhage rate, and the presence of alloimmunity. Upon the occurrence of severe FMH, it can rapidly lead to intrauterine distress, fetal anemia, and the possibility of fetal demise, presenting a considerable threat to both maternal and neonatal well-being. In this article, I present a substantial case of FMH and conduct a systematic review of the current scientific literature regarding the etiology, clinical manifestations, diagnostic approaches, treatment highlights, and prognosis of this condition. The objective of this work is to improve clinicians' comprehension and diagnostic proficiency concerning FMH.

摘要

胎儿-母体出血(FMH)是一种复杂的产科情况,主要发生在妊娠晚期或分娩时。其隐匿且非特异性的发病往往导致诊断困难。尽管FMH的潜在病理生理学主要归因于胎盘屏障受损,但其仍未被完全理解。该病症的严重程度与失血量、出血速度以及同种免疫的存在密切相关。严重FMH发生时,可迅速导致宫内窘迫、胎儿贫血以及胎儿死亡的可能性,对母婴健康构成相当大的威胁。在本文中,我呈现了一例严重的FMH病例,并对当前关于该病症的病因、临床表现、诊断方法、治疗要点及预后的科学文献进行了系统综述。这项工作的目的是提高临床医生对FMH的理解和诊断能力。

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