Xiong Binglang, Zhang Cheng, Cao Xuhan, Guo Ziyan, Bai Zixing, Sun Weidong
Second Department of Orthopedics, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
Third Department of Orthopedics, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
Front Med (Lausanne). 2024 Oct 9;11:1413174. doi: 10.3389/fmed.2024.1413174. eCollection 2024.
Low-dose aspirin is widely used as a preventive medication for cardiovascular diseases. However, there is controversy regarding the impact of low-dose aspirin on articular cartilage. The aim of this study is to explore the association between low-dose aspirin intake and osteoarthritis (OA).
We conducted a cross-sectional study based on the United States population data from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. The investigation of low-dose aspirin intake and the diagnosis of OA was based on self-reporting in questionnaires. Multivariate regression models was used to assess the relationship between low-dose aspirin intake and OA. In addition, subgroup and interaction analysis were performed to assess the robustness of the results.
A total of 12,215 participants were included in this study. Multivariate logistic regression analysis showed that low-dose aspirin use had significantly increased the odds of OA (OR = 1.14; 95% CI: 1.01-1.28; = 0.035). A significant and consistent association of low-dose aspirin intake with OA was still observed in each subgroup stratified by gender, age, and the presence of comorbidities including diabetes, coronary heart disease, hypertension, and stroke. The results illustrated that the relationship between low-dose aspirin intake and OA was stable in all subgroups and had no interaction.
Our study confirmed that low-dose aspirin intake may increase the risk of OA. Attention should be paid to the possibility of joint degenerative changes in patients who take low-dose aspirin chronically. However, further studies are needed to explore the possible mechanisms behind this association.
低剂量阿司匹林被广泛用作心血管疾病的预防药物。然而，低剂量阿司匹林对关节软骨的影响存在争议。本研究的目的是探讨低剂量阿司匹林摄入与骨关节炎（OA）之间的关联。
我们基于2011 - 2018年美国国家健康与营养检查调查（NHANES）的人群数据进行了一项横断面研究。低剂量阿司匹林摄入情况的调查和OA的诊断基于问卷中的自我报告。使用多变量回归模型评估低剂量阿司匹林摄入与OA之间的关系。此外，进行了亚组分析和交互作用分析以评估结果的稳健性。
本研究共纳入12215名参与者。多变量逻辑回归分析表明，使用低剂量阿司匹林显著增加了患OA的几率（比值比 = 1.14；95%置信区间：1.01 - 1.28；P = 0.035）。在按性别、年龄以及是否存在包括糖尿病、冠心病、高血压和中风在内的合并症分层的每个亚组中，仍观察到低剂量阿司匹林摄入与OA之间存在显著且一致的关联。结果表明，低剂量阿司匹林摄入与OA之间的关系在所有亚组中都是稳定的，且不存在交互作用。
我们的研究证实，低剂量阿司匹林摄入可能会增加患OA的风险。对于长期服用低剂量阿司匹林的患者，应注意其关节退行性变化的可能性。然而，需要进一步研究来探索这种关联背后的可能机制。
