Lee Song Hee, Dubey Namo, Jeon Junhyun
Plant Immunity Research Center, Seoul National University, Seoul, Korea.
Department of Biotechnology, College of Life and Applied Sciences, Yeungnam University, Gyeongsan, Gyeongbuk, Korea.
Mycobiology. 2024 Jul 22;52(4):214-221. doi: 10.1080/12298093.2024.2379623. eCollection 2024.
Nucleolus is the most conspicuous sub-nuclear compartment that is well known as the site of RNA polymerase I-mediated rDNA transcription and assembly of ribosome subunits in eukaryotes. Recent studies on mammalian cells suggest that functions of nucleolus are not limited to ribosome biogenesis, and that nucleolus is involved in a diverse array of nuclear and cellular processes such as DNA repair, stress responses, and protein sequestration. In fungi, knowledge of nucleolus and its functions was primarily gleaned from the budding yeast. However, little is known about nucleolus of the filamentous fungi. Considering that the filamentous fungi are multi-cellular eukaryotes and thus distinct from the yeast in many aspects, researches on nucleoli of filamentous fungi would have the potential to uncover the evolution of nucleolus and its roles in the diverse cellular processes. Here we provide a brief up-to-date overview of nucleolus in general, and evidence suggesting their roles in fungal physiology and development.
核仁是最显著的亚核区室，在真核生物中，它是RNA聚合酶I介导的核糖体DNA转录和核糖体亚基组装的场所。最近对哺乳动物细胞的研究表明，核仁的功能不仅限于核糖体生物合成，而且还参与多种核和细胞过程，如DNA修复、应激反应和蛋白质隔离。在真菌中，关于核仁及其功能的知识主要来自酿酒酵母。然而，对于丝状真菌的核仁却知之甚少。鉴于丝状真菌是多细胞真核生物，在许多方面与酵母不同，对丝状真菌核仁的研究有可能揭示核仁的进化及其在各种细胞过程中的作用。在此，我们简要概述一下核仁的最新情况，并提供证据表明它们在真菌生理和发育中的作用。
