Pentafluorosulfanylation of Acrylamides: The Synthesis of SF-Containing Isoquinolinediones with SFCl.

We disclose herein an efficient and facile method for the synthesis of SF-containing isoquinolinediones with an all-carbon quaternary stereocenter via intramolecular pentafluorosulfanylation of acrylamides using SFCl as a pentafluorosulfanylation reagent. The protocol proceeds under mild reaction conditions and enjoys a broad substrate scope, wide functional group compatibility, and high atom- and step-economy. A radical mechanism involving the SF radical cascade addition/cyclization of acrylamides is proposed.