Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, PR China.
Joint Laboratory of Optofluidic Technology and System,National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou, 510006, PR China.
Mikrochim Acta. 2024 Oct 24;191(11):697. doi: 10.1007/s00604-024-06766-7.
An innovative methodology is proposed for quantifying Gefitinib (GFT) using an electrochemical sensor constructed from a composite of graphene quantum dots (GQDs) and gold nanoparticles (AuNPs). GQDs were synthesized from graphite, preserving graphene's large surface area and excellent electron transfer capabilities while enhancing dispersibility. The combination of GQDs with AuNPs resulted in an AuNPs@GQDs composite, which was used to construct the sensor. The synthesized nanomaterials were characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and the electrochemical performance of the sensor was evaluated via cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Under optimized conditions, the sensor displayed a linear calibration curve for GFT detection within the range 0.01 to 10.0 µM, with a limit of detection (LOD) of 0.005 µM (S/N = 3). The sensor demonstrated excellent anti-interference properties and stability in tests using pharmaceutical formulations and plasma samples. Compared to chromatographic methods, the sensor exhibited similar accuracy and recovery. Its easy fabrication and high sensitivity make it a promising tool for pharmaceutical analysis and clinical therapeutic drug monitoring.
提出了一种使用基于石墨烯量子点（GQDs）和金纳米粒子（AuNPs）复合材料构建的电化学传感器定量检测吉非替尼（GFT）的创新方法。GQDs 是从石墨合成的，保留了石墨烯的大表面积和优异的电子转移能力，同时提高了分散性。GQDs 与 AuNPs 的结合产生了 AuNPs@GQDs 复合材料，该复合材料被用于构建传感器。通过扫描电子显微镜（SEM）和透射电子显微镜（TEM）对合成的纳米材料进行了表征，并通过循环伏安法（CV）和差分脉冲伏安法（DPV）评估了传感器的电化学性能。在优化条件下，该传感器在 0.01 至 10.0 µM 的范围内对 GFT 检测呈现出线性校准曲线，检测限（LOD）为 0.005 µM（S/N = 3）。该传感器在药物制剂和血浆样品测试中表现出良好的抗干扰性和稳定性。与色谱方法相比，该传感器具有相似的准确性和回收率。其易于制造和高灵敏度使其成为药物分析和临床治疗药物监测的有前途的工具。
