Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Department of Neurosurgery, First People's Hospital of Yibin, Yibin, Sichuan, China.
Department of Neurology, First People's Hospital of Yibin, Yibin, Sichuan, China.
Cytokine. 2024 Dec;184:156789. doi: 10.1016/j.cyto.2024.156789. Epub 2024 Oct 23.
Cytokines are potent molecules of the immune response. They act at the site of inflammation and circulate in the bloodstream. However, there are few studies on encephalitis and circulating inflammatory proteins.
In this study, Mendelian randomization (MR) was used to explore the potential causal effect of 91 circulating inflammatory proteins on 3 different types of encephalitis. Causal effects were examined using Steiger, MR-Egger, weighted median, and inverse variance weighting (IVW) methods. IVW methods were primarily used for results interpretation. In addition, sensitivity analyses were performed, including assessment of heterogeneity, horizontal pleiotropy, and Leave-one-out techniques.
We subjected 91 circulating inflammatory proteins to MR analysis of causality with each of the three types of encephalitis. The results suggested that the inflammatory factors with a potential causal relationship with viral encephalitis were caspase 8, C-X-C motif chemokine 6, interleukin-10, interleukin-15 receptor subunit alpha, interleukin-7, and TNF-beta. Inflammatory factors potentially causally associated with acute disseminated encephalomyelitis are beta-nerve growth factor, cystatin D, interleukin-7, Latency-associated peptide transforming growth factor beta 1,and neurotrophin-3.Inflammatory factors potentially causally associated with autoimmune encephalitis are C-C motif chemokine 25, hepatocyte growth factor, latency-associated peptide transforming growth factor beta 1, programmed cell death 1 ligand 1, sulfotransferase 1A1, and tumor necrosis factor.
This finding identifies potential causal effects of certain circulating inflammatory factors on susceptibility to three types of encephalitis. It also suggests the therapeutic potential of modulating the levels of these cytokines. A basis for further research is provided.
细胞因子是免疫反应的有力分子。它们在炎症部位发挥作用，并在血液中循环。然而，关于脑炎和循环炎症蛋白的研究较少。
在这项研究中，我们使用孟德尔随机化（MR）来探索 91 种循环炎症蛋白对 3 种不同类型脑炎的潜在因果效应。使用 Steiger、MR-Egger、加权中位数和逆方差加权（IVW）方法来检验因果效应。IVW 方法主要用于结果解释。此外，还进行了敏感性分析，包括评估异质性、水平多效性和Leave-one-out 技术。
我们对 91 种循环炎症蛋白进行了与三种脑炎的因果关系的 MR 分析。结果表明，与病毒性脑炎有潜在因果关系的炎症因子是半胱氨酸蛋白酶 8、C-X-C 基序趋化因子 6、白细胞介素 10、白细胞介素 15 受体亚单位α、白细胞介素 7 和 TNF-β。与急性播散性脑脊髓炎有潜在因果关系的炎症因子是β-神经生长因子、胱抑素 D、白细胞介素 7、Latency-associated peptide transforming growth factor beta 1 和神经营养素-3。与自身免疫性脑炎有潜在因果关系的炎症因子是 C-C 基序趋化因子 25、肝细胞生长因子、Latency-associated peptide transforming growth factor beta 1、程序性细胞死亡 1 配体 1、磺基转移酶 1A1 和肿瘤坏死因子。
本研究发现了某些循环炎症因子对三种脑炎易感性的潜在因果效应，并提示了调节这些细胞因子水平的治疗潜力。为进一步研究提供了依据。
