College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; Guangdong Technological Engineering Research Center for Pet, Guangzhou, China.
College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Microb Pathog. 2024 Dec;197:107057. doi: 10.1016/j.micpath.2024.107057. Epub 2024 Oct 22.
In June 2020, Lumpy Skin Disease Virus (LSDV) was first discovered in Guangdong, China. Whole-genome sequencing and evolutionary analysis indicate that this strain represents a novel recombinant vaccine strain. Our investigation has identified regions affected by LSD outbreaks prior to 2024, revealing widespread prevalence of LSDV across East Asia and Southeast Asia. Subsequent analysis of the physical and chemical characteristics of the strain revealed LSDV's resilience to high temperatures, varying pH levels, humidity, UV radiation, and light exposure. Among the tested disinfectants, potassium persulfate, glutaraldehyde, and benzalkonium bromide have demonstrated the most potent virucidal efficacy against LSDV while maintaining high safety profiles. Utilizing the Syrian hamster model, infection with this strain has resulted in the formation of skin nodules and testicular damage, providing valuable insights into the pathogenesis of LSDV. In conclusion, the comprehensive experimental data presented herein serve as a cornerstone for advancing biosafety protocols, facilitating effective prevention and control strategies, and fostering the development of small animal model for LSDV.
2020 年 6 月，在中国广东首次发现了水疱性皮肤病病毒（LSDV）。全基因组测序和进化分析表明，该毒株代表了一种新型重组疫苗株。我们的调查确定了 LSD 爆发前受影响的地区，揭示了 LSDV 在东亚和东南亚的广泛流行。随后对该毒株的物理和化学特性进行分析表明，LSDV 能够耐受高温、不同 pH 值、湿度、UV 辐射和光照。在测试的消毒剂中，过硫酸钾、戊二醛和苯扎溴铵对 LSDV 表现出最强的病毒杀灭效果，同时保持了很高的安全性。利用叙利亚仓鼠模型，该毒株感染导致皮肤结节和睾丸损伤，为 LSDV 的发病机制提供了有价值的见解。总之，本文提供的全面实验数据为推进生物安全协议、制定有效的预防和控制策略以及促进 LSDV 小动物模型的发展奠定了基础。
