Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Life Sci. 2024 Dec 1;358:123159. doi: 10.1016/j.lfs.2024.123159. Epub 2024 Oct 23.
RNA-binding proteins (RBPs) and non-coding RNAs are crucial trans-acting factors that bind to specific cis-acting elements in mRNAs, thereby regulating their stability and translation. The trans-activation response (TAR) RNA-binding protein (TRBP) recognizes precursor microRNAs (pre-miRNAs), modulates miRNA maturation, and influences miRNA interference (mi-RNAi) mediated by the RNA-induced silencing complex (RISC). TRBP also directly binds and mediates the degradation of certain mRNAs. Thus, TRBP acts as a hub for regulating gene expression and influences a variety of biological processes, including immune evasion, metabolic abnormalities, stress response, angiogenesis, hypoxia, and metastasis. Aberrant TRBP expression has been proven to be closely related to the initiation and progression of diseases, such as viral infection, chronic metabolic diseases, brain disorders, and cancer. This review summarizes the roles of TRBP in cancer and other diseases, the therapeutic potential of TRBP inhibition, and the current status of drug discovery on TRBP.
RNA 结合蛋白 (RBPs) 和非编码 RNA 是至关重要的反式作用因子，它们与 mRNA 中的特定顺式作用元件结合，从而调节其稳定性和翻译。TAR RNA 结合蛋白 (TRBP) 识别前体 microRNAs (pre-miRNAs)，调节 miRNA 的成熟，并影响 RNA 诱导的沉默复合物 (RISC) 介导的 miRNA 干扰 (mi-RNAi)。TRBP 还直接结合并介导某些 mRNA 的降解。因此，TRBP 作为调节基因表达的枢纽，影响多种生物学过程，包括免疫逃逸、代谢异常、应激反应、血管生成、缺氧和转移。已经证明，TRBP 的异常表达与疾病的发生和进展密切相关，如病毒感染、慢性代谢疾病、脑疾病和癌症。本综述总结了 TRBP 在癌症和其他疾病中的作用、TRBP 抑制的治疗潜力以及 TRBP 药物发现的现状。
