'Click' hydrogels from renewable polysaccharide resources: Bioorthogonal chemistry for the preparation of alginate, cellulose and other plant-based networks with biomedical applications.

Click chemistry refers to a class of highly selective reactions that occur in one pot, are not disturbed by water or oxygen, proceed quickly to high yield and generate only inoffensive byproducts. Since its first definition by Barry Sharpless in 2001, click chemistry has increasingly been used for the preparation of hydrogels, which are water-swollen polymer networks with numerous biomedical applications. Polysaccharides, which can be obtained from renewable resources including plants, have drawn growing attention for use in hydrogels due to the recent focus on the development of a sustainable society and the reduction of the environmental impact of the chemical industry. Importantly, plant-based polysaccharides are often bioresorbable and exhibit excellent biocompatibility and biomimicry. This comprehensive review describes the synthesis, characterization and biomedical applications of hydrogels which combine the renewable and biocompatible aspects of polysaccharides with the chemically and biomedically favorable characteristics of click crosslinking. The manuscript focuses on click hydrogels prepared from alginate and cellulose, the most widely used polysaccharides for this type of hydrogel, but also click hydrogels based on other plant-derived polymers (e.g. pectin) are discussed. In addition, the challenges are described that should be overcome to facilitate translation from academia to the clinic.