Evancho Alexandra, Do Melissa, Fortenberry Damiana, Billings Rebecca, Sartayev Alibek, Tyler William J
University of Alabama at Birmingham School of Health Professions, Birmingham, AL, USA.
University of Alabama at Birmingham School of Engineering, Birmingham, AL, USA.
NPJ Parkinsons Dis. 2024 Oct 24;10(1):199. doi: 10.1038/s41531-024-00803-1.
Parkinson's Disease (PD) is a prevalent, progressive neurodegenerative disease with motor and non-motor symptoms. Vagus Nerve Stimulation (VNS) has emerged as a potential therapeutic approach for PD, but published research on this topic varies widely. This scoping review maps existing literature on VNS for PD, highlighting stimulation methods, operational parameters, safety profiles, neurophysiological mechanisms, and clinical outcomes in human and animal models. Online databases were used to identify 788 papers published between 2013 and 2023, from which 17 publications on invasive and non-invasive VNS in PD were selected. Studies showed high variability in VNS parameters and study design. Evidence in animal models and human subjects suggests potential neurophysiological effects on PD-related pathology and motor function improvements. However, significant gaps in the literature remain. Future research should include rigorous reporting of study design, standardization of stimulation parameters, and larger sample sizes to ultimately facilitate translation of VNS into clinical practice.
帕金森病（PD）是一种常见的、进行性神经退行性疾病，具有运动和非运动症状。迷走神经刺激（VNS）已成为治疗PD的一种潜在方法，但关于该主题的已发表研究差异很大。本综述梳理了关于PD的VNS现有文献，重点介绍了刺激方法、操作参数、安全性、神经生理机制以及人类和动物模型中的临床结果。通过在线数据库识别了2013年至2023年间发表的788篇论文，从中选取了17篇关于PD的侵入性和非侵入性VNS的出版物。研究表明，VNS参数和研究设计存在高度变异性。动物模型和人类受试者的证据表明，VNS对PD相关病理和运动功能改善具有潜在的神经生理效应。然而，文献中仍存在重大空白。未来的研究应包括严格报告研究设计、标准化刺激参数以及扩大样本量，以最终促进VNS转化为临床实践。
