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女性下尿路症状患者中逼尿肌活动低下和膀胱出口梗阻的流行率及其预测因素。

Prevalence and predictors of detrusor underactivity and bladder outlet obstruction in women with lower urinary tract symptoms.

机构信息

Department of Obstetrics and Gynecology, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu City, 300195, Taiwan.

Department of Obstetrics and Gynecology, National Taiwan University College of Medicine and Hospital, No. 8, Zhongshan S. Rd., Zhongzheng Dist., Taipei City, 100225, Taiwan.

出版信息

Sci Rep. 2024 Oct 24;14(1):25141. doi: 10.1038/s41598-024-76242-y.

Abstract

This study aims to present age-stratified prevalence of women with lower urinary tract symptoms (LUTS) but without cystocele and predict detrusor underactivity (DU) or bladder outlet obstruction (BOO). Between 2005 and 2020, we reviewed women who visited the medical center with LUTS but without cystocele. Positive voiding dysfunction (VD) symptoms were defined as any one or more of the positive descriptions of weak urinary stream, intermittency, strain to urination, and sensation of not emptying. A total of 1,886 women were included in this study. 189 (10.0%) women were diagnosed with DU, and 77 (4.1%) women had BOO. Multivariate logistic regression analysis found that voided volume and VD symptoms were independent predictors for BOO. ROC curve analyses could predict BOO by voided volume ≤ 220 mL derived from uroflowmetry and the presence of VD symptoms with an area under a curve of 0.83. Age and voided volume could predict DU with an area under a curve of 0.82. We found a higher percentage of BOO in women with positive VD symptoms. A non-invasive uroflowmetry with voided volume (≤ 220 mL) and the presence of VD symptoms can predict BOO. DU could be predicted by age and voided volume.

摘要

本研究旨在呈现无膀胱膨出的下尿路症状(LUTS)女性的年龄分层患病率,并预测逼尿肌活动低下(DU)或膀胱出口梗阻(BOO)。在 2005 年至 2020 年间,我们回顾了因 LUTS 但无膀胱膨出而到医疗中心就诊的女性。阳性排尿功能障碍(VD)症状定义为任何一种或多种以下阳性描述:尿流弱、间歇性、排尿困难和未排空感。共有 1886 名女性纳入本研究。189 名(10.0%)女性被诊断为 DU,77 名(4.1%)女性有 BOO。多变量逻辑回归分析发现,排尿量和 VD 症状是 BOO 的独立预测因素。ROC 曲线分析表明,尿流率检测得出的排尿量≤220ml 以及存在 VD 症状可以预测 BOO,曲线下面积为 0.83。年龄和排尿量可以预测 DU,曲线下面积为 0.82。我们发现,阳性 VD 症状的女性中 BOO 的比例更高。非侵入性尿流率检测结合排尿量(≤220ml)和 VD 症状的存在可以预测 BOO。DU 可以通过年龄和排尿量预测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e40/11502903/e943116c5292/41598_2024_76242_Fig1_HTML.jpg

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