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迷你巩膜镜对慢性眼移植物抗宿主病（GvHD）患者的视觉和眼表面益处。

Visual and ocular surface benefits of mini-scleral contact lenses in patients with chronic ocular graft-versus-host disease (GvHD).

机构信息

Eye Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Augenarztpraxis Prof. Grüb, Bahnhofstraße 7, 79206, Breisach, Germany.

出版信息

Sci Rep. 2024 Oct 24;14(1):25254. doi: 10.1038/s41598-024-76249-5.

DOI:10.1038/s41598-024-76249-5
PMID:39448772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11502835/
Abstract

Graft-versus-Host disease is a major complication of allogeneic stem cell transplantation. The eyes are a frequently affected organ with a severe dry eye disease being the hallmark manifestation. This retrospective study evaluates the effect of mini-scleral contact lenses on visual acuity, eye-related quality of life and the ocular surface. 62 eyes of 31 patients were included and visual acuity, ocular surface disease index (OSDI) questionnaire results and Oxford grades before and after mini-scleral lens fitting were compared. Median Snellen fraction with mini-scleral lenses was 20/25 (1st 20/30/3rd 20/20) compared to 20/40 median Snellen fraction with spectacles (1st 20/60/3rd 20/25). Median OSDI scores improved from 73 (1st 41.6/3rd 89) before fitting to 27 (1st 14.5/3rd 56) with mini-scleral lenses. Median Oxford grade decreased from 3 before mini-scleral lens fitting (1st 1/3rd 4.75) to 1 after mini-scleral lens fitting (1st 0/3rd 4). Median time of follow up was 717.5 days. Seven patients (22.6%) discontinued therapy with mini-scleral lenses. Mini-scleral lenses are beneficial for most patients with ocular GvHD as they improve visual acuity, eye-related quality of life and the integrity of the corneal epithelium.

摘要

移植物抗宿主病是异基因干细胞移植的主要并发症。眼睛是受影响的常见器官，严重的干眼症是其主要表现。本回顾性研究评估了迷你巩膜接触镜对视力、眼部相关生活质量和眼表的影响。共纳入 31 例 62 只眼，比较了迷你巩膜镜适配前后的视力、眼表疾病指数（OSDI）问卷结果和牛津分级。与戴眼镜的中位数 Snellen 分数 20/40（1 分 20/60/3 分 20/25）相比，迷你巩膜镜的中位数 Snellen 分数为 20/25（1 分 20/30/3 分 20/20）。在适配迷你巩膜镜之前，OSDI 评分中位数为 73（1 分 41.6/3 分 89），而在适配后为 27（1 分 14.5/3 分 56）。在适配迷你巩膜镜之前，牛津分级中位数为 3（1 分 1/3 分 4.75），而在适配后为 1（1 分 0/3 分 4）。中位随访时间为 717.5 天。7 名患者（22.6%）停止了迷你巩膜镜治疗。迷你巩膜镜对大多数眼部 GvHD 患者有益，因为它们可以提高视力、眼部相关生活质量和角膜上皮的完整性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/11502835/6df737d4ab85/41598_2024_76249_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/11502835/cad751c9be99/41598_2024_76249_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/11502835/906dbbb18980/41598_2024_76249_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/11502835/3bd9703da7ba/41598_2024_76249_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/11502835/6df737d4ab85/41598_2024_76249_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/11502835/cad751c9be99/41598_2024_76249_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/11502835/906dbbb18980/41598_2024_76249_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/11502835/3bd9703da7ba/41598_2024_76249_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/11502835/6df737d4ab85/41598_2024_76249_Fig4_HTML.jpg

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本文引用的文献

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CLEAR - Scleral lenses.硬性透气性角膜接触镜。
Cont Lens Anterior Eye. 2021 Apr;44(2):270-288. doi: 10.1016/j.clae.2021.02.001. Epub 2021 Mar 25.
2
The official guide to scleral lens terminology.巩膜镜术语官方指南。
Cont Lens Anterior Eye. 2020 Dec;43(6):529-534. doi: 10.1016/j.clae.2019.09.006. Epub 2019 Sep 25.
3
Ocular surface system alterations in ocular graft-versus-host disease: all the pieces of the complex puzzle.眼部移植物抗宿主病中的眼表系统改变：复杂谜题的所有碎片。
Graefes Arch Clin Exp Ophthalmol. 2019 Jul;257(7):1341-1351. doi: 10.1007/s00417-019-04301-6. Epub 2019 Apr 3.
4
Scleral lenses for severe chronic GvHD-related keratoconjunctivitis sicca: a retrospective study by the SFGM-TC.用于严重慢性移植物抗宿主病相关干燥性角结膜炎的巩膜镜：法国移植物抗宿主病研究与治疗协作组的一项回顾性研究
Bone Marrow Transplant. 2017 Jun;52(6):878-882. doi: 10.1038/bmt.2017.9. Epub 2017 Feb 20.
5
Use of Prosthetic Replacement of the Ocular Surface Ecosystem Scleral Lenses in Patients with Ocular Chronic Graft-versus-Host Disease.在眼部慢性移植物抗宿主病患者中使用眼表生态系统巩膜镜的假体置换
Biol Blood Marrow Transplant. 2015 Dec;21(12):2180-2184. doi: 10.1016/j.bbmt.2015.07.027. Epub 2015 Jul 31.
6
Scleral lens use in dry eye syndrome.巩膜镜在干眼综合征中的应用。
Curr Opin Ophthalmol. 2015 Jul;26(4):319-24. doi: 10.1097/ICU.0000000000000171.
7
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.美国国立卫生研究院慢性移植物抗宿主病临床试验标准共识发展项目：I. 2014年诊断与分期工作组报告
Biol Blood Marrow Transplant. 2015 Mar;21(3):389-401.e1. doi: 10.1016/j.bbmt.2014.12.001. Epub 2014 Dec 18.
8
Modern scleral contact lenses: A review.现代巩膜接触镜：综述
Cont Lens Anterior Eye. 2014 Aug;37(4):240-50. doi: 10.1016/j.clae.2014.02.002. Epub 2014 Mar 12.
9
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10
International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: proposed diagnostic criteria for chronic GVHD (Part I).国际慢性眼部移植物抗宿主病（GVHD）共识小组：慢性GVHD的拟诊标准（第一部分）
Sci Rep. 2013 Dec 5;3:3419. doi: 10.1038/srep03419.