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Next-generation sequencing and high DNA input identify previously missed measurable residual disease in peripheral blood of B-cell precursor acute lymphoblastic leukaemia.

作者信息

Bendig Sonja, Bufe Sandra, Kotrova Michaela, Fricke Birgit, Proske Constantin, Darzentas Franziska, Darzentas Nikos, Schilhabel Anke, Kehden Britta, Chitadze Guranda, Baldus Claudia D, Gökbuget Nicola, Brüggemann Monika

机构信息

Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.

Clinical Research Unit 'CATCH ALL' (KFO 5010/1) Funded by the Deutsche Forschungsgemeinschaft, Kiel, Germany.

出版信息

Br J Haematol. 2025 Jan;206(1):353-356. doi: 10.1111/bjh.19834. Epub 2024 Oct 24.

DOI:10.1111/bjh.19834
PMID:39449173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11739763/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963e/11739763/98084dee1579/BJH-206-353-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963e/11739763/3b30d7fa32db/BJH-206-353-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963e/11739763/98084dee1579/BJH-206-353-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963e/11739763/3b30d7fa32db/BJH-206-353-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/963e/11739763/98084dee1579/BJH-206-353-g002.jpg

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Next-generation sequencing and high DNA input identify previously missed measurable residual disease in peripheral blood of B-cell precursor acute lymphoblastic leukaemia.新一代测序和高DNA输入量可识别B细胞前体急性淋巴细胞白血病外周血中先前遗漏的可测量残留疾病。
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The : How to define the hemodilution of bone marrow samples in lymphoproliferative diseases.《：如何定义淋巴增殖性疾病中骨髓样本的血液稀释》 （此标题翻译可能不太准确，因为原标题表述不太完整规范，但按照要求逐字翻译了）
Front Oncol. 2022 Oct 6;12:1001048. doi: 10.3389/fonc.2022.1001048. eCollection 2022.
2
Progression and survival of MBL: a screening study of 10 139 individuals.MBL 的进展和生存情况：一项针对 10139 人的筛查研究。
Blood. 2022 Oct 13;140(15):1702-1709. doi: 10.1182/blood.2022016279.
3
Comparison of minimal residual disease levels in bone marrow and peripheral blood in adult acute lymphoblastic leukemia.
成人急性淋巴细胞白血病患者骨髓与外周血微小残留病水平的比较。
Leukemia. 2020 Apr;34(4):1154-1157. doi: 10.1038/s41375-019-0599-1. Epub 2019 Oct 22.
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Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study.采用标准化的下一代免疫球蛋白和 T 细胞受体基因重排测序技术鉴定急性淋巴细胞白血病微小残留病（MRD）标志物：一项 EuroClonality-NGS 验证研究。
Leukemia. 2019 Sep;33(9):2241-2253. doi: 10.1038/s41375-019-0496-7. Epub 2019 Jun 26.
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Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies.急性淋巴细胞白血病伴分子学复发的成年患者预后不良，是干细胞移植和靶向治疗的候选人群。
Blood. 2012 Aug 30;120(9):1868-76. doi: 10.1182/blood-2011-09-377713. Epub 2012 Mar 22.
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Leukemia. 2003 Jun;17(6):1013-34. doi: 10.1038/sj.leu.2402922.