Tscholl R, Rehmann B, Stierli P, Locher J
J Urol. 1986 Mar;135(3):629-33. doi: 10.1016/s0022-5347(17)45765-x.
Radionuclide procedures are clinically used for assessing obstruction in dilated urinary tracts. The precise correlation of the isotope retention function with the level of the renal pelvic pressure is not known as yet. It was measured experimentally using 20 minipigs. By means of ureterostomies in situ reaching into the pyelon the 40 kidneys were subjected to varying pressures (seven to 62 cm. H2O) while the renal processing of 123-I-orthoiodine-hippuric-acid was recorded. The correlation of five radionuclide parameters with the pelvic pressure was computed: the time to the peak value of the isotope nephrography (t-max) and renal transit time correlated very well with high grade pelvic pressure (greater than 37 cm. H2O): r = 0.91 and 0.86 respectively, but much less well with low grade pelvic pressure (less than 37 cm. H2O): r = 0.73 and 0.62 respectively. The slope of the third phase of the isotope nephrography (tan-turn) and the time to the turning point of its tangent (t-turn) correlated only weakly with elevated renal pelvic pressure: r = 0.62 and 0.59 respectively. In conclusion, radionuclide procedures give excellent qualitative information on the level of pelvic pressure. They cannot, however, be used even as an indirect means for quantitatively assessing elevated renal pelvic pressure, which in urinary obstruction is thought to be one of the factors jeopardizing renal function.
放射性核素检查在临床上用于评估扩张尿路的梗阻情况。目前尚不清楚同位素滞留功能与肾盂压力水平之间的确切相关性。我们使用20只小型猪进行了实验测量。通过在原位将输尿管造口术延伸至肾盂，使40个肾脏承受不同压力（7至62厘米水柱），同时记录123-I-邻碘马尿酸的肾脏处理过程。计算了五个放射性核素参数与肾盂压力的相关性：同位素肾图峰值时间（t-max）和肾转运时间与高等级肾盂压力（大于37厘米水柱）相关性很好：r分别为0.91和0.86，但与低等级肾盂压力（小于37厘米水柱）相关性较差：r分别为0.73和0.62。同位素肾图第三阶段的斜率（tan-turn）及其切线转折点时间（t-turn）与升高的肾盂压力相关性较弱：r分别为0.62和0.59。总之，放射性核素检查能提供关于肾盂压力水平的出色定性信息。然而，它们甚至不能作为间接手段用于定量评估升高的肾盂压力，而肾盂压力在尿路梗阻中被认为是危及肾功能的因素之一。
