Jex R K, Schaff H V, Piehler J M, King R M, Orszulak T A, Danielson G K, Pairolero P C, Pluth J R, Ilstrup D
J Vasc Surg. 1986 Feb;3(2):226-37. doi: 10.1067/mva.1986.avs0030226.
Management of dissections of the descending thoracic aorta remains controversial, especially with regard to timing and method of repair. To clarify these and other issues we have reviewed our total experience with repair of descending aortic dissections between 1962 and 1983. The 44 men and 20 women had a mean (+/- SEM) age of 59 +/- 2 years (range, 19 to 83 years), and in all patients the dissection originated in and was limited to the aorta distal to the left carotid artery (Stanford type B, DeBakey types IIIa and IIIb). Twenty-nine patients underwent operation within 2 weeks of the onset of symptoms (acute), and the remainder had later repair (chronic). During repair, circulation distal to the aortic cross-clamp was supported with cardiopulmonary bypass or shunt in two thirds of patients. Overall, 18 deaths occurred less than or equal to 30 days postoperatively (operative risk 28%), and risk was higher in acute (45%) than in chronic (14%) dissections. Operative risk was not significantly related to protection of the distal circulation. The most serious postoperative complication was spinal cord ischemia manifested by paraplegia in five patients (8%) and transient or permanent paraparesis in six patients (9%). Risk of spinal cord ischemia was significantly lower in patients who had protection of the distal circulation during operative repair (8% vs. 44%, p = 0.003). Late survival, including hospital deaths, was 49% +/- 7% at 5 years after operation; 22 of the 46 patients who survived repair were found to have aneurysms involving the thoracic and/or abdominal segments of the aorta. Our results indicate that repair of chronic dissection of the thoracic aorta has a lower operative risk than repair of acute dissections, and initial medical management of acute dissection may be indicated if no early complications occur. Risk of spinal cord ischemia is significantly reduced by cardiopulmonary bypass or shunt and is preferred over aortic cross-clamping alone. Finally, these patients require careful long-term follow-up because of the high incidence of residual or recurrent aortic aneurysms.
胸降主动脉夹层的治疗仍存在争议,尤其是在修复时机和方法方面。为了阐明这些及其他问题,我们回顾了1962年至1983年间胸降主动脉夹层修复的全部经验。44例男性和20例女性的平均(±标准误)年龄为59±2岁(范围为19至83岁),所有患者的夹层均起源于左颈动脉远端的主动脉并局限于此(斯坦福B型,德巴凯IIIa型和IIIb型)。29例患者在症状出现后2周内接受了手术(急性),其余患者接受了后期修复(慢性)。在修复过程中,三分之二的患者通过体外循环或分流术支持主动脉交叉钳夹远端的循环。总体而言,术后30天内有18例死亡(手术风险28%),急性夹层(45%)的风险高于慢性夹层(14%)。手术风险与远端循环的保护无显著相关性。最严重的术后并发症是脊髓缺血,表现为5例患者(8%)截瘫,6例患者(9%)短暂或永久性轻瘫。在手术修复期间有远端循环保护的患者脊髓缺血风险显著降低(8%对44%,p = 0.003)。包括住院死亡在内的术后5年生存率为49%±7%;46例修复后存活的患者中有22例被发现患有累及胸主动脉和/或腹主动脉段的动脉瘤。我们的结果表明,胸主动脉慢性夹层的修复手术风险低于急性夹层,如果没有早期并发症,急性夹层可能需要初始药物治疗。体外循环或分流术可显著降低脊髓缺血风险,优于单纯主动脉交叉钳夹。最后,由于残留或复发性主动脉瘤的发生率较高,这些患者需要仔细的长期随访。