Zhang Chuanqiang, Fu Fengqing, Zhu Xingchao, Ni Xiangyu, Yue Sijia, Wu Hongya, Shi Tongguo
Department of General Surgery, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Curr Med Chem. 2024 Oct 24. doi: 10.2174/0109298673332052241008060857.
In the current review, we aim to elucidate the advancements concerning the roles and fundamental mechanisms of intermittent fasting (IF) and fasting-mimicking diet (FMD) in cancers. As a dietary intervention,IF and FMD potentially impede tumor growth by modulating multiple signaling pathways, such as AKT, Nrf2, and AMPK pathways.Moreover, IF and FMD have been reported to be associated with the tumor immune response by regulating various immune cells including tumor-associated macrophages (TAMs), monocytic myeloid-derived suppressor cells (MDSCs), T cells, and B cells.Additionally, IF and FMD can enhance the efficacy and tolerability of therapy, concurrently reducing therapy-induced side effects. Furthermore, several clinical trials have underscored the safety, feasibility, and positive impact on the quality of life associated with IF and FMD, thereby augmenting the effectiveness of conventional anti-- tumor therapies while ameliorating treatment-related side effects. This review provides a comprehensive synthesis of findings and elucidates the underlying mechanisms of IF and FMD in cancer progression and therapy.
在当前的综述中，我们旨在阐明间歇性禁食（IF）和模拟禁食饮食（FMD）在癌症中的作用及基本机制方面的进展。作为一种饮食干预措施，IF和FMD可能通过调节多种信号通路（如AKT、Nrf2和AMPK通路）来阻碍肿瘤生长。此外，据报道，IF和FMD通过调节包括肿瘤相关巨噬细胞（TAM）、单核细胞来源的髓系抑制细胞（MDSC）、T细胞和B细胞在内的各种免疫细胞与肿瘤免疫反应相关。此外，IF和FMD可以提高治疗的疗效和耐受性，同时减少治疗引起的副作用。此外，几项临床试验强调了与IF和FMD相关的安全性、可行性以及对生活质量的积极影响，从而在改善与治疗相关的副作用的同时增强了传统抗肿瘤治疗的有效性。本综述对研究结果进行了全面总结，并阐明了IF和FMD在癌症进展和治疗中的潜在机制。
